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Robert J. Gorelick
Researcher at Leidos
Publications - 39
Citations - 2734
Robert J. Gorelick is an academic researcher from Leidos. The author has contributed to research in topics: Nucleic acid & RNA. The author has an hindex of 20, co-authored 39 publications receiving 2256 citations. Previous affiliations of Robert J. Gorelick include United States Department of Commerce & University of Minnesota.
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Journal ArticleDOI
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
Marina Caskey,Florian Klein,Julio C. C. Lorenzi,Michael S. Seaman,Anthony P. West,Noreen Buckley,Gisela Kremer,Lilian Nogueira,Malte Braunschweig,Johannes F. Scheid,Joshua A. Horwitz,Irina Shimeliovich,Sivan Ben-Avraham,Maggi Witmer-Pack,Martin Platten,Clara Lehmann,Leah A. Burke,Thomas Hawthorne,Robert J. Gorelick,Bruce D. Walker,Tibor Keler,Roy M. Gulick,Gerd Fätkenheuer,Sarah J. Schlesinger,Michel C. Nussenzweig +24 more
TL;DR: It is concluded that, as a single agent, 3BNC117 is safe and effective in reducing HIV-1 viraemia, and that immunotherapy should be explored as a new modality for HIV- 1 prevention, therapy and cure.
Journal ArticleDOI
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
Rebecca M. Lynch,Eli Boritz,Emily E. Coates,Adam DeZure,Patrick J Madden,Pamela Costner,Mary E. Enama,Sarah H. Plummer,LaSonji A. Holman,Cynthia S. Hendel,Ingelise J. Gordon,Joseph P. Casazza,Michelle Conan-Cibotti,Stephen A. Migueles,Randall Tressler,Robert T. Bailer,Adrian B. McDermott,Sandeep Narpala,Sijy O'Dell,Gideon Wolf,Jeffrey D. Lifson,Brandie A. Freemire,Robert J. Gorelick,Janardan P. Pandey,Sarumathi Mohan,Nicolas Chomont,Rémi Fromentin,Tae-Wook Chun,Anthony S. Fauci,Richard M. Schwartz,Richard A. Koup,Daniel C. Douek,Zonghui Hu,Edmund V. Capparelli,Barney S. Graham,John R. Mascola,Julie E. Ledgerwood,Vrc Study Team +37 more
TL;DR: A single infusion of mAb VRC01 significantly decreased plasma viremia and preferentially suppressed neutralization-sensitive virus strains, demonstrating the virological effect of this neutralizing antibody and highlighting the need for combination strategies to maintain virus suppression.
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Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo
Francesco R. Simonetti,Michele D. Sobolewski,Elizabeth Fyne,Wei Shao,Jonathan Spindler,Junko Hattori,Elizabeth M. Anderson,Sarah A. Watters,Shawn Hill,Xiaolin Wu,David Wells,Li Su,Brian T. Luke,Elias K. Halvas,Guillaume Besson,Kerri J. Penrose,Zhiming Yang,Richard Kwan,Carter Van Waes,Thomas S. Uldrick,Deborah Citrin,Joseph A. Kovacs,Michael A. Polis,Catherine Rehm,Robert J. Gorelick,Michael Piatak,Brandon F. Keele,Mary F. Kearney,John M. Coffin,Stephen H. Hughes,John W. Mellors,Frank Maldarelli +31 more
TL;DR: Results show that clonally expanded CD4+T cells can be a reservoir of infectious HIV-1, and it is reported that a highly expandedCD4+ T-cell clone contains an intact provirus.
Journal ArticleDOI
The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent.
TL;DR: The data strongly suggest that the two Zn2+ fingers of HIV-1 are not functionally equivalent and that the first Zn1+ finger in the Gag precursor plays a more prominent role in RNA selection and packaging, and indicate that both Zn 2+ fingers in the mature NC protein play as yet unknown roles in viral assembly or the early stages of the viral infection process.
Journal ArticleDOI
Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.
Donn J Colby,Lydie Trautmann,Lydie Trautmann,Suteeraporn Pinyakorn,Suteeraporn Pinyakorn,Louise Leyre,Amélie Pagliuzza,Eugene Kroon,Morgane Rolland,Morgane Rolland,Hiroshi Takata,Hiroshi Takata,Supranee Buranapraditkun,Jintana Intasan,Nitiya Chomchey,Roshell Muir,Elias K. Haddad,Sodsai Tovanabutra,Sodsai Tovanabutra,Sasiwimol Ubolyam,Diane L. Bolton,Diane L. Bolton,Brandie A. Fullmer,Robert J. Gorelick,Lawrence Fox,Trevor A Crowell,Trevor A Crowell,Rapee Trichavaroj,Robert J. O'Connell,Nicolas Chomont,Jerome H. Kim,Jerome H. Kim,Nelson L. Michael,Merlin L. Robb,Merlin L. Robb,Nittaya Phanuphak,Jintanat Ananworanich +36 more
TL;DR: Initiation of antiretroviral therapy in the first 2 weeks of HIV infection fails to prevent resurgence of virus after stopping treatment, indicating early establishment of a resilient viral reservoir.