R
Robert S. Fulton
Researcher at Washington University in St. Louis
Publications - 254
Citations - 167513
Robert S. Fulton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 109, co-authored 230 publications receiving 143530 citations. Previous affiliations of Robert S. Fulton include University of Washington & Brown University.
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Journal ArticleDOI
A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing
Allegra A. Petti,Stephen R. Williams,Christopher A. Miller,Ian T. Fiddes,Sridhar Nonavinkere Srivatsan,David Y. Chen,Catrina Fronick,Robert S. Fulton,Deanna M. Church,Timothy J. Ley +9 more
TL;DR: A general approach for linking mutation-containing cells to their transcriptional phenotypes using single-cell RNA sequencing data is described, broadly applicable to any sample that is phenotypically and genetically heterogeneous.
Journal ArticleDOI
Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia.
Michelle L. Churchman,Maoxiang Qian,Geertruy te Kronnie,Ranran Zhang,Wenjian Yang,Hui Zhang,Tobia Lana,Paige Tedrick,Rebekah Baskin,Katherine Verbist,Jennifer L. Peters,Meenakshi Devidas,Eric Larsen,Ian Moore,Zhaohui Gu,Chunxu Qu,Hiroki Yoshihara,Shaina N. Porter,Shondra M. Pruett-Miller,Gang Wu,Elizabeth A. Raetz,Paul L. Martin,W. Paul Bowman,Naomi J. Winick,Elaine R. Mardis,Robert S. Fulton,Martin Stanulla,William E. Evans,Mary V. Relling,Ching-Hon Pui,Stephen P. Hunger,Mignon L. Loh,Rupert Handgretinger,Kim E. Nichols,Jun J. Yang,Charles G. Mullighan +35 more
TL;DR: Coding germline IKZF1 variation in familial childhood ALL and 0.9% of presumed sporadic B-ALL is reported, identifying 28 unique variants in 45 children and emphasizing the importance of germline genetic variation in the development of both familial and sporadic ALL.
Journal ArticleDOI
Single haplotype assembly of the human genome from a hydatidiform mole
Karyn Meltz Steinberg,Valerie A. Schneider,Tina A. Graves-Lindsay,Robert S. Fulton,Richa Agarwala,John Huddleston,Sergey A. Shiryev,Aleksandr Morgulis,Urvashi Surti,Wesley C. Warren,Deanna M. Church,Evan E. Eichler,Richard K. Wilson +12 more
TL;DR: Analysis of gene, repetitive element, and segmental duplication content show this assembly to be of excellent quality and contiguity, however, comparison to assembly-independent resources, such as BAC clone end sequences and PacBio long reads, indicate misassembled regions.
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Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Marina Cella,Ramya Gamini,Cristiane Sécca,Patrick L. Collins,Patrick L. Collins,Shanrong Zhao,Vincent Peng,Michelle L. Robinette,Michelle L. Robinette,Jorge Schettini,Konstantin Zaitsev,Konstantin Zaitsev,William Gordon,Jennifer K. Bando,Kentaro Yomogida,Victor S. Cortez,Victor S. Cortez,Catrina Fronick,Robert S. Fulton,Lih Ling Lin,Susan Gilfillan,Richard A. Flavell,Liang Shan,Maxim N. Artyomov,Michael R. Bowman,Eugene M. Oltz,Eugene M. Oltz,Scott A. Jelinsky,Marco Colonna +28 more
TL;DR: It is shown that human innate lymphoid cells undergo conversion from ILC3s into ILC1-like cells in tissues in vivo, and that tissue factors and Aiolos were required for this process.
Journal ArticleDOI
The Human Pangenome Project: a global resource to map genomic diversity
Ting Wang,L. L. Antonacci-Fulton,Kerstin Howe,Heather A. Lawson,Julian K. Lucas,Adam M. Phillippy,Alice B. Popejoy,Mobin Asri,Caryn Nicole Carson,Mark Chaisson,Xian Chang,Robert Cook-Deegan,Adam Felsenfeld,Robert S. Fulton,Erik Garrison,Nanibaa’ A. Garrison,Tina A. Graves-Lindsay,Hanlee P. Ji,Eimear E. Kenny,Barbara A. Koenig,Daofeng Li,Tobias Marschall,Joshua F. McMichael,Adam M. Novak,Deepak Purushotham,Valerie A. Schneider,Baergen I. Schultz,M. Smith,Heidi J. Sofia,Tsachy Weissman,Paul Flicek,Heng Li,Karen H. Miga,Benedict Paten,Erich D. Jarvis,Ira M. Hall,Evan E. Eichler,David Haussler +37 more
TL;DR: The Human Pangenome Reference Consortium (HPRC) as discussed by the authors aims to create a more sophisticated and complete human reference genome with a graph-based, telomere-to-telomere representation of global genomic diversity.