scispace - formally typeset
R

Robert S. Fulton

Researcher at Washington University in St. Louis

Publications -  254
Citations -  167513

Robert S. Fulton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 109, co-authored 230 publications receiving 143530 citations. Previous affiliations of Robert S. Fulton include University of Washington & Brown University.

Papers
More filters
Journal ArticleDOI

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

Katherine A Hoadley, +738 more
- 05 Apr 2018 - 
TL;DR: Molecular similarities among histologically or anatomically related cancer types provide a basis for focused pan-cancer analyses, such as pan-gastrointestinal, Pan-gynecological, pan-kidney, and pan-squamous cancers, and those related by stemness features, which may inform strategies for future therapeutic development.
Journal ArticleDOI

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Jinghui Zhang, +73 more
- 12 Jan 2012 - 
TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Journal ArticleDOI

BreakDancer: An algorithm for high resolution mapping of genomic structural variation

Ken Chen, +15 more
- 09 Aug 2009 - 
TL;DR: The algorithm BreakDancer predicts a wide variety of structural variants including insertion-deletions (indels), inversions and translocations and sensitively and accurately detected indels ranging from 10 base pairs to 1 megabase pair that are difficult to detect via a single conventional approach.
Journal ArticleDOI

The origin and evolution of mutations in acute myeloid leukemia.

John S. Welch, +53 more
- 20 Jul 2012 - 
TL;DR: The data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is "captured" as the clone expands.
Journal ArticleDOI

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Li Ding, +68 more
- 15 Apr 2010 - 
TL;DR: The differential mutation frequencies and structural variation patterns in metastasis and xenograft compared with the primary tumour indicate that secondary tumours may arise from a minority of cells within thePrimary tumour.