Robert S. Fulton

TL;DR: It is shown that patients with obesity at the time of diagnosis of cervical cancer exhibit improved outcomes after radiation, and PI3K/AKT pathway mutations are common in obese patients, but are not associated with activation of AKT signaling.

TL;DR: Using exome sequencing, RNA-sequencing, and functional immunologic studies, this article characterized 28 normal karyotype (NK)-AML patients with >5 y first remissions after chemotherapy (LFRs).

TL;DR: There is no evidence that chemotherapy induces genome-wide DNA damage in t-AML, and a model in which rare TP53 mutant-bearing HSC clones have a selective growth advantage in patients undergoing chemotherapy is proposed.

TL;DR: An approach that integrates enhanced whole genome sequencing with the 10x Genomics Chromium Single Cell 5’ Gene Expression workflow to directly link expressed mutations with transcriptional profiles at single cell resolution is developed and is broadly applicable for analysis of any sample that is phenotypically and genetically heterogeneous.

TL;DR: In this paper, the coding region of 750 genes in 1,094 rheumatoid arthritis patients of European ancestry treated with anti-TNF medications were sequenced, and the authors found that rare and low-frequency protein-coding variants in TNF signaling pathway genes or other genes do not contribute substantially to RA patients.