R
Robert S. Fulton
Researcher at Washington University in St. Louis
Publications - 254
Citations - 167513
Robert S. Fulton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 109, co-authored 230 publications receiving 143530 citations. Previous affiliations of Robert S. Fulton include University of Washington & Brown University.
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Journal ArticleDOI
A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa.
Lori S. Sullivan,Daniel C. Koboldt,Sara J. Bowne,Steven Lang,Susan H. Blanton,Elizabeth Cadena,Cheryl E. Avery,Richard A. Lewis,Kaylie Webb-Jones,Dianna K H Wheaton,David G. Birch,Razck Coussa,Huanan Ren,Irma Lopez,Christina Chakarova,Robert K. Koenekoop,Charles A. Garcia,Robert S. Fulton,Richard K. Wilson,George M. Weinstock,Stephen P. Daiger +20 more
TL;DR: It is hypothesized that the effect of this mutation is limited to the retina, as no systemic abnormalities in glycolysis were detected and the whole-exome next-generation sequencing identified an HK1 mutation in five adRP families.
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Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.
Malachi Griffith,Obi L. Griffith,Kilannin Krysiak,Zachary L. Skidmore,Matthew J. Christopher,Jeffery M. Klco,Avinash Ramu,Tamara Lamprecht,Alex H. Wagner,Katie M. Campbell,Robert Lesurf,Jasreet Hundal,Jin Zhang,Nicholas C. Spies,Benjamin J. Ainscough,David E. Larson,Sharon Heath,Catrina Fronick,Shelly O'Laughlin,Robert S. Fulton,Vincent Magrini,Sean McGrath,Scott M. Smith,Christopher A. Miller,Christopher G. Maher,Jacqueline E. Payton,Jason Walker,James M. Eldred,Matthew J. Walter,Daniel C. Link,Timothy A. Graubert,Peter Westervelt,Shashikant Kulkarni,John F. DiPersio,Elaine R. Mardis,Rick K. Wilson,Timothy J. Ley +36 more
TL;DR: Comprehensive genome and transcriptome characterization revealed a dramatic tumor evolution during progression, yielding a tumor with complex clonal architecture at second relapse, and an unexpected, actionable therapeutic target that led to a specific therapy associated with a rapid clinical response.
Journal ArticleDOI
Co-evolution of tumor and immune cells during progression of multiple myeloma
Ruiyang Liu,Qingsong Gao,Steven M. Foltz,Jared S. Fowles,Lijun Yao,Julia Tianjiao Wang,Song Cao,Hua Sun,Michael C. Wendl,Sunantha Sethuraman,Amila Weerasinghe,Michael P. Rettig,Erik Storrs,Christopher J. Yoon,Matthew A. Wyczalkowski,Joshua F. McMichael,Daniel R. Kohnen,Justin King,Scott R. Goldsmith,Julie O'Neal,Robert S. Fulton,Catrina Fronick,Timothy J. Ley,Reyka G Jayasinghe,Mark A. Fiala,Stephen T. Oh,John F. DiPersio,Ravi Vij,Li Ding +28 more
TL;DR: In this article, a longitudinal investigation for tumor and micro-environment during multiple myeloma (MM) progression is presented, which paves the way for expanding treatment options and revealing patients with the same genetic alterations tend to have both plasma cells and immune cells clustered together.
Journal ArticleDOI
Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Jinghui Zhang,Li Ding,Linda Holmfeldt,Gang Wu,Susan L. Heatley,Debbie Payne-Turner,John Easton,Xiang Chen,Jianmin Wang,Michael Rusch,Charles Lu,Shann-Ching Chen,Racquel Collins-Underwood,Jing Ma,Kathryn G. Roberts,Stanley Pounds,Lei Wei,Anatoly Ulyanov,Jared Becksfort,Pankaj Gupta,Robert Huether,Richard W. Kriwacki,Daniel J. McGoldrick,David Zhao,Daniel Alford,Stephen Espy,Kiran Chand Bobba,Guangchun Song,Deqing Pei,Cheng Cheng,Stefan Roberts,Michael I. Barbato,Dario Campana,Elaine Coustan-Smith,William E. Evans,Sheila A. Shurtleff,Maria Kleppe,Jan Cools,Kristin A. Shimano,Michelle L. Hermiston,Sergei Doulatov,Kolja Eppert,Elisa Laurenti,Faiyaz Notta,John E. Dick,Giuseppe Basso,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,Brent L. Wood,Stuart S. Winter,Kimberly P. Dunsmore,Robert S. Fulton,Lucinda Fulton,Xin Hong,Chris Harris,David J. Dooling,Kerri Ochoa,Kimberly J. Johnson,John C. Obenauer,Ching-Hon Pui,Susana C. Raimondi,Clayton W. Naeve,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Charles G. Mullighan +67 more
TL;DR: Results of whole genome sequencing of tumor and normal DNA from 12 children with ETP ALL show a high frequency of activating mutations in genes regulating cytokine receptor and Ras signalling are identified, including GATA3 regulates early T cell development, and mutations in this gene were observed exclusively in ETP All.
Journal ArticleDOI
Clonal evolution revealed by whole genome sequencing in a case of primary myelofibrosis transformed to secondary acute myeloid leukemia.
Elizabeth K. Engle,Daniel A.C. Fisher,Christopher A. Miller,Michael D. McLellan,Robert S. Fulton,Deborah M. Moore,Richard K. Wilson,Timothy J. Ley,Stephen T. Oh +8 more
TL;DR: Genomic analyses of a patient with primary myelofibrosis transformed to secondary acute myeloid leukemia (sAML) illustrate the complex clonal dynamics associated with disease evolution in MPNs and sAML.