R
Robert S. Fulton
Researcher at Washington University in St. Louis
Publications - 254
Citations - 167513
Robert S. Fulton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 109, co-authored 230 publications receiving 143530 citations. Previous affiliations of Robert S. Fulton include University of Washington & Brown University.
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Journal ArticleDOI
[18F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility
Linda Eissenberg,Michael P. Rettig,Julie Ritchey,Julie L. Prior,Sally W. Schwarz,Jennifer Frye,Brian S. White,Robert S. Fulton,Armin Ghobadi,Matthew L. Cooper,Daniel R. Couriel,Muhammad Esa Seegulam,David Piwnica-Worms,Farrokh Dehdashti,Kenneth Cornetta,John F. DiPersio +15 more
TL;DR: This phase 1 trial demonstrated that genetically modified T cells and [18F]FHBG can be safely infused in patients with relapsed hematologic malignancies after allogeneic stem cell transplantation.
Journal ArticleDOI
Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.
Eric J. Duncavage,Geoffrey L. Uy,Allegra A. Petti,Christopher A. Miller,Yi-Shan Lee,Bevan Tandon,Feng Gao,Catrina Fronick,Michelle O'Laughlin,Robert S. Fulton,Richard K. Wilson,Meagan A. Jacoby,Amanda F. Cashen,Lukas D. Wartman,Matthew J. Walter,Peter Westervelt,Daniel C. Link,John F. DiPersio,Timothy J. Ley,John S. Welch +19 more
TL;DR: Quantitative response evaluation in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDSs) relies on the morphologic quantification of bone marrow blasts, subject to the operator-dependent quality of BM collection and the interobserver variability.
Journal ArticleDOI
Truncating Prolactin Receptor Mutations Promote Tumor Growth in Murine Estrogen Receptor-Alpha Mammary Carcinomas
Obi L. Griffith,Szeman Ruby Chan,Malachi Griffith,Kilannin Krysiak,Zachary L. Skidmore,Jasreet Hundal,Julie A. Allen,Cora D. Arthur,Daniele Runci,Mattia Bugatti,Alexander P. Miceli,Heather Schmidt,Lee Trani,Krishna-Latha Kanchi,Christopher A. Miller,David E. Larson,Robert S. Fulton,William Vermi,William Vermi,Rick K. Wilson,Robert D. Schreiber,Elaine R. Mardis +21 more
TL;DR: This investigation identified somatic truncating mutations affecting the prolactin receptor (PRLR) in all tumor and no normal samples and confirmed the presence of these mutations in precancerous lesions, indicating that this is an early event in tumorigenesis.
Posted ContentDOI
High-Quality Assembly of an Individual of Yoruban Descent
Karyn Meltz Steinberg,Tina A. Graves-Lindsay,Valerie A. Schneider,Mark Chaisson,Chad Tomlinson,John Huddleston,Patrick Minx,Milinn Kremitzki,Derek Albrecht,Vincent Magrini,Sean McGrath,Archana Raja,Carl Baker,Lana Harshman,LaDeana W. Hillier,Françoise Thibaud-Nissen,Nathan Bouk,Amy Ly,Chris T. Amemiya,Joyce Tang,Evan E. Eichler,Robert S. Fulton,Wesley C. Warren,Deanna M. Church,Richard K. Wilson +24 more
TL;DR: This work uses PacBio single-molecule, real-time (SMRT) sequencing and BioNano genomic maps to construct the first de novo assembly of NA19240, a Yoruban individual from Africa, and demonstrates that diploid assembly has utility in improving the quality of de noVO human genome assemblies.
Posted ContentDOI
Single haplotype assembly of the human genome from a hydatidiform mole
Karyn Meltz Steinberg,Valerie K Schneider,Tina A. Graves-Lindsay,Robert S. Fulton,Richa Agarwala,John Huddleston,Sergey A Shiryayev,Aleksandr Morgulis,Urvashi Surti,Wesley C. Warren,Deanna M. Church,Evan E. Eichler,Richard K. Wilson +12 more
TL;DR: An accurate and complete reference human genome sequence assembly is essential for accurately interpreting individual genomes and associating sequence variation with disease phenotypes and comparisons to ClinVar and the NHGRI GWAS catalog show that the CHM1 genome does not harbor an excess of deleterious alleles.