R
Robert S. Fulton
Researcher at Washington University in St. Louis
Publications - 254
Citations - 167513
Robert S. Fulton is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 109, co-authored 230 publications receiving 143530 citations. Previous affiliations of Robert S. Fulton include University of Washington & Brown University.
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Journal ArticleDOI
A draft human pangenome reference
Wen-Wei Liao,Mobin Asri,Jana Ebler,Daniel Doerr,Marina Haukness,Glenn Hickey,Shuangjia Lu,Julian K. Lucas,Jean Marcel Maurice Monlong,Haley J. Abel,Silvia Buonaiuto,Xian Chang,Haoyu Cheng,Justin Jang Hann Chu,Vincenza Colonna,Jordan M. Eizenga,Xiaowen Feng,Christian Fischer,Robert S. Fulton,Shilpa Garg,Cristian Groza,Andrea Guarracino,William T. Harvey,Simon Heumos,Kerstin Howe,Miten Jain,Tsung-Yu Lu,Charles Markello,Fergal J. Martin,Matthew Mitchell,Katherine M. Munson,Moses N. Mwaniki,Adam M. Novak,Hugh E. Olsen,Trevor Pesout,David Porubsky,Pjotr Prins,Jonas Andreas Sibbesen,Chad Tomlinson,Flavia Villani,Mitchell R. Vollger,Guillaume Bourque,Mark Chaisson,Paul Flicek,Adam M. Phillippy,Justin M. Zook,Evan E. Eichler,David Haussler,Erich D. Jarvis,Karen H. Miga,Ting Wang,Erik Garrison,Tobias Marschall,Ira M. Hall,Heng Li,Benedict Paten +55 more
TL;DR: The pangenome reference as discussed by the authors contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals and is more than 99% accurate at the structural and base pair levels.
Journal ArticleDOI
Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children
Heng Xu,Heng Xu,Hui Zhang,Hui Zhang,Wenjian Yang,Rachita Yadav,Alanna C. Morrison,Maoxiang Qian,Meenakshi Devidas,Yu Liu,Virginia Perez-Andreu,Xujie Zhao,Julie M. Gastier-Foster,Philip J. Lupo,Geoff Neale,Elizabeth A. Raetz,Eric Larsen,W. Paul Bowman,William L. Carroll,Naomi J. Winick,Richard Williams,Torben Hansen,Jens-Christian Holm,Elaine R. Mardis,Robert S. Fulton,Ching-Hon Pui,Jinghui Zhang,Charles G. Mullighan,William E. Evans,Stephen P. Hunger,Ramneek Gupta,Kjeld Schmiegelow,Mignon L. Loh,Mary V. Relling,Jun J. Yang +34 more
TL;DR: In this paper, a missense variant in CDKN2A was associated with the development of ALL at genome-wide significance (rs3731249, P=9.4 × 10(-23), odds ratio=2.23).
Posted ContentDOI
Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP
Matthew A. Lalli,S Joshua Langmade,Xuhua Chen,Catrina Fronick,Christopher S. Sawyer,Lauren C. Burcea,Michael N. Wilkinson,Robert S. Fulton,Michael E. Heinz,William Buchser,Richard D. Head,Robi D. Mitra,Jeffrey Milbrandt +12 more
TL;DR: Preliminary results demonstrate a promising approach to overcome the current bottlenecks limiting widespread testing of rapid colorimetric assays using reverse-transcription loop-mediated isothermal amplification optimized on human saliva samples without an RNA purification step.
Journal ArticleDOI
Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci.
Tanya M. Teslovich,Christian Fuchsberger,Vasily Ramensky,Pranav Yajnik,Daniel C. Koboldt,David E. Larson,Qunyuan Zhang,Ling Lin,Ryan P. Welch,Li Ding,Michael D. McLellan,Michele O'Laughlin,Catrina Fronick,Lucinda Fulton,Vincent Magrini,Amy J. Swift,Paul Elliott,Marjo-Riitta Järvelin,Marika Kaakinen,Mark I. McCarthy,Leena Peltonen,Leena Peltonen,Anneli Pouta,Lori L. Bonnycastle,Francis S. Collins,Narisu Narisu,Heather M. Stringham,Jaakko Tuomilehto,Samuli Ripatti,Robert S. Fulton,Chiara Sabatti,Richard K. Wilson,Michael Boehnke,Nelson B. Freimer +33 more
TL;DR: The results highlight the value of large, well-phenotyped samples for rare-variant association analysis, and the challenge of evaluating the phenotypic impact of such variants.
Journal ArticleDOI
Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia
Seth E. Karol,Leonard A. Mattano,Wenjian Yang,Kelly W. Maloney,Colton Smith,Chengcheng Liu,Laura B. Ramsey,Christian A. Fernandez,Tamara Chang,Geoffrey Neale,Cheng Cheng,Elaine R. Mardis,Robert S. Fulton,Paul Scheet,F. Anthony San Lucas,Eric C. Larsen,Mignon L. Loh,Elizabeth A. Raetz,Stephen P. Hunger,Meenakshi Devidas,Mary V. Relling +20 more
TL;DR: Top replicated SNPs were enriched in enhancers active in mesenchymal stem cells, and analysis of annotated genes demonstrated enrichment in glutamate receptor and adipogenesis pathways, which may provide new insights into the pathophysiology of osteonecrosis.