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Robert Tibshirani
Researcher at Stanford University
Publications - 620
Citations - 359457
Robert Tibshirani is an academic researcher from Stanford University. The author has contributed to research in topics: Lasso (statistics) & Gene expression profiling. The author has an hindex of 147, co-authored 593 publications receiving 326580 citations. Previous affiliations of Robert Tibshirani include University of Toronto & University of California.
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Genome-wide Measurement of RNA Folding Energies
Yue Wan,Kun Qu,Zhengqing Ouyang,Zhengqing Ouyang,Michael Kertesz,Jun Li,Robert Tibshirani,Debora L. Makino,Robert C. Nutter,Eran Segal,Howard Y. Chang +10 more
TL;DR: By probing yeast RNA structures at different temperatures, relative melting temperatures (Tm) are obtained for RNA structures in over 4000 transcripts and specific signatures of RNA Tm demarcated the polarity of mRNA open reading frames and highlighted numerous candidate regulatory RNA motifs in 3' untranslated regions.
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In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
Youn H. Kim,Dita Gratzinger,Cameron Harrison,Joshua Brody,Debra K. Czerwinski,Weiyun Z. Ai,Anjali V. Morales,Farah Abdulla,Leon Xing,Daniel Navi,Robert Tibshirani,Ranjana H. Advani,Bharathi Lingala,Sumit A. Shah,Richard T. Hoppe,Ronald Levy +15 more
TL;DR: The in situ vaccination strategy that combines local radiation to enhance tumor immunogenicity with the injection into the tumor of a TLR9 agonist is explored in a second disease: mycosis fungoides.
Journal Article
Estimation of Sparse Binary Pairwise Markov Networks using Pseudo-likelihoods
Holger Höfling,Robert Tibshirani +1 more
TL;DR: An approximate procedure based on the pseudo-likelihood of Besag (1975) is implemented and this procedure is faster than the competing exact method proposed by Lee, Ganapathi, and Koller (2006a) and only slightly less accurate.
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Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification
Young Ho Kim,Luc Girard,Craig P. Giacomini,Pei Wang,Tina Hernandez-Boussard,Robert Tibshirani,John D. Minna,Jonathan R. Pollack +7 more
TL;DR: The findings support a role of altered apoptotic balance in the pathogenesis of SCLC, and suggest that MYC family genes might affect oncogenesis through distinct sets of targets, in particular implicating the importance of transcriptional repression.
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A Network Model of a Cooperative Genetic Landscape in Brain Tumors
Markus Bredel,Denise M. Scholtens,Griffith R. Harsh,Claudia Bredel,Claudia Bredel,James P. Chandler,Jaclyn J. Renfrow,Ajay Yadav,Hannes Vogel,Adrienne C. Scheck,Robert Tibshirani,Branimir I. Sikic +11 more
TL;DR: A network model of a cooperative genetic landscape in gliomas shows that mutations, which are likely due to nonrandom selection of a distinct genetic landscape during gliomagenesis, are associated with patient prognosis.