R
Rork Kuick
Researcher at University of Michigan
Publications - 166
Citations - 17557
Rork Kuick is an academic researcher from University of Michigan. The author has contributed to research in topics: Gene & Gene expression profiling. The author has an hindex of 60, co-authored 166 publications receiving 16459 citations. Previous affiliations of Rork Kuick include University of Florida.
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Journal ArticleDOI
Gene-expression profiles predict survival of patients with lung adenocarcinoma
David G. Beer,Sharon L.R. Kardia,Chiang Ching Huang,Thomas J. Giordano,Albert M. Levin,David E. Misek,Lin Lin,Guoan Chen,Tarek G. Gharib,Dafydd G. Thomas,Michelle L. Lizyness,Rork Kuick,Satoru Hayasaka,Jeremy M. G. Taylor,Mark D. Iannettoni,Mark B. Orringer,Samir M. Hanash +16 more
TL;DR: The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy.
Journal ArticleDOI
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
Guido T. Bommer,Isabelle Gerin,Ying Feng,Andrew J. Kaczorowski,Rork Kuick,Robert E. Love,Yali Zhai,Thomas J. Giordano,Zhaohui S. Qin,Bethany B. Moore,Ormond A. MacDougald,Kathleen R. Cho,Eric R. Fearon +12 more
TL;DR: The data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers.
Journal ArticleDOI
Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study.
Kerby Shedden,Jeremy M. G. Taylor,Steven A. Enkemann,Ming-Sound Tsao,Timothy J. Yeatman,William L. Gerald,Steven A. Eschrich,Igor Jurisica,Thomas J. Giordano,David E. Misek,Andrew C. Chang,Chang-Qi Zhu,Daniel Strumpf,Samir M. Hanash,Frances A. Shepherd,Keyue Ding,Lesley Seymour,Katsuhiko Naoki,Nathan A. Pennell,Barbara A. Weir,Roeland Verhaak,Christine Ladd-Acosta,Todd R. Golub,Michael Gruidl,Anupama Sharma,Janos Szoke,Maureen F. Zakowski,Valerie W. Rusch,Mark G. Kris,Agnes Viale,Noriko Motoi,William D. Travis,Barbara A. Conley,Venkatraman E. Seshan,Matthew Meyerson,Matthew Meyerson,Rork Kuick,Kevin K. Dobbin,Tracy Lively,James W. Jacobson,David G. Beer +40 more
TL;DR: A large, training–testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas, providing the largest available set of microarray data with extensive pathological and clinical annotation for lungAdenocARCinomas.
Journal Article
Gene expression in ovarian cancer reflects both morphology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian carcinomas.
Donald R. Schwartz,Sharon L.R. Kardia,Kerby Shedden,Rork Kuick,George Michailidis,Jeremy M. G. Taylor,David E. Misek,Rong Wu,Yali Zhai,Danielle M. Darrah,Heather Reed,Lora Hedrick Ellenson,Thomas J. Giordano,Eric R. Fearon,Samir M. Hanash,Kathleen R. Cho +15 more
TL;DR: The data indicate that gene expression patterns in ovarian adenocarcinomas reflect both morphological features and biological behavior, and provide a foundation for the development of new type-specific diagnostic strategies and treatments for ovarian cancer.
Journal ArticleDOI
Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans
Sharlene Murdoch,Ugljesa Djuric,Batool Mazhar,Muheiddine Seoud,Rabia T. Khan,Rork Kuick,Rashmi Bagga,Renate Kircheisen,Asangla Ao,Bhawna Ratti,Samir M. Hanash,Guy A. Rouleau,Rima Slim +12 more
TL;DR: Five mutations in the maternal gene NALP7 in individuals with familial and recurrent HMs are reported, which is the first maternal effect gene identified in humans and is also responsible for recurrent spontaneous abortions, stillbirths and intrauterine growth retardation.