R
Ruben Boers
Researcher at Erasmus University Rotterdam
Publications - 22
Citations - 366
Ruben Boers is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: DNA methylation & Gene. The author has an hindex of 5, co-authored 16 publications receiving 213 citations. Previous affiliations of Ruben Boers include Erasmus University Medical Center.
Papers
More filters
Journal ArticleDOI
RNF12 activates Xist and is essential for X chromosome inactivation.
Tahsin Stefan Barakat,Nilhan Gunhanlar,Cristina Gontan Pardo,Eskeatnaf Mulugeta Achame,Mehrnaz Ghazvini,Ruben Boers,Annegien Kenter,Eveline Rentmeester,J. Anton Grootegoed,Joost Gribnau +9 more
TL;DR: It is demonstrated that the dose dependent X-encoded XCI activator RNF12/RLIM acts in trans and activates Xist, thereby leading to initiation of random XCI.
Journal ArticleDOI
Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI.
Ruben Boers,Joachim Boers,Bas de Hoon,Christel E M Kockx,Zeliha Ozgur,Anco Molijn,Wilfred F. J. van IJcken,Joop S.E. Laven,Joost Gribnau +8 more
TL;DR: Methylated DNA sequencing (MeD-seq) of LpnPI digested fragments revealed highly reproducible genome-wide CpG methylation profiles for >50% of all potentially methylated CpGs, at a sequencing depth less than one-tenth required for whole-genome bisulfite sequencing (WGBS).
Journal ArticleDOI
SPEN haploinsufficiency causes a neurodevelopmental disorder overlapping proximal 1p36 deletion syndrome with an episignature of X chromosomes in females
Francesca Clementina Radio,Kaifang Pang,Andrea Ciolfi,Michael A. Levy,Andres Hernandez-Garcia,Lucia Pedace,Francesca Pantaleoni,Zhandong Liu,Elke de Boer,Adam Jackson,Adam Jackson,Alessandro Bruselles,Haley McConkey,Emilia Stellacci,Stefania Lo Cicero,Marialetizia Motta,Rosalba Carrozzo,Maria Lisa Dentici,Kirsty McWalter,Megha Desai,Kristin G. Monaghan,Aida Telegrafi,Christophe Philippe,Antonio Vitobello,Margaret Au,Katheryn Grand,Pedro A. Sanchez-Lara,Joanne Baez,Kristin Lindstrom,Peggy Kulch,Jessica Sebastian,Suneeta Madan-Khetarpal,Chelsea Roadhouse,Jennifer MacKenzie,Berrin Monteleone,Carol J Saunders,July K. Jean Cuevas,Laura A Cross,Dihong Zhou,Taila Hartley,Sarah L. Sawyer,Fabíola Paoli Monteiro,Tania Vertemati Secches,Fernando Kok,Laura Schultz-Rogers,Erica L. Macke,Eva Morava,Eric W. Klee,Jennifer L. Kemppainen,Maria Iascone,Angelo Selicorni,Romano Tenconi,David J. Amor,Lynn Pais,Lyndon Gallacher,Peter D. Turnpenny,Karen Stals,Sian Ellard,Sara Cabet,Gaetan Lesca,Joset Pascal,Katharina Steindl,Sarit Ravid,Karin Weiss,Alison M R Castle,Melissa T. Carter,Louisa Kalsner,Bert B.A. de Vries,Bregje W.M. van Bon,Marijke R. Wevers,Rolph Pfundt,Alexander P.A. Stegmann,Bronwyn Kerr,Helen Kingston,Kate Chandler,Willow Sheehan,Abdallah F. Elias,Deepali N. Shinde,Meghan C. Towne,Nathaniel H. Robin,Dana H. Goodloe,Adeline Vanderver,Adeline Vanderver,Omar Sherbini,Krista Bluske,R. Tanner Hagelstrom,Caterina Zanus,Flavio Faletra,Luciana Musante,Evangeline Kurtz-Nelson,Rachel K. Earl,Britt-Marie Anderlid,Gilles Morin,Marjon van Slegtenhorst,Karin E. M. Diderich,Alice S. Brooks,Joost Gribnau,Ruben Boers,Teresa Robert Finestra,Lauren Carter,Anita Rauch,Paolo Gasparini,Paolo Gasparini,Kym M. Boycott,Tahsin Stefan Barakat,John M. Graham,Laurence Faivre,Siddharth Banka,Siddharth Banka,Tianyun Wang,Evan E. Eichler,Manuela Priolo,Bruno Dallapiccola,Lisenka E.L.M. Vissers,Bekim Sadikovic,Daryl A. Scott,Jimmy Holder,Marco Tartaglia +117 more
TL;DR: In this article, the authors used clinical data from 34 individuals with truncating variants in SPEN to define a neurodevelopmental disorder presenting with features that overlap considerably with those of proximal del1p36 syndrome.
Journal ArticleDOI
Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion
Robin L. Adrianse,Kaleb Smith,Tonibelle N. Gatbonton-Schwager,Smitha Sripathy,Uyen Lao,Eric J. Foss,Ruben Boers,Joachim Boers,Joost Gribnau,Antonio Bedalov,Antonio Bedalov +10 more
TL;DR: The results demonstrate that Xist plays a role in the maintenance of histone repressive marks, DNA methylation and transcriptional repression on the inactive X-chromosome, but that partial loss of X-dosage compensation in the absence of Xist in the brain is well tolerated.
Journal ArticleDOI
Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation.
Manzhi Zhao,Caoimhe H. Kiernan,Christopher J. Stairiker,Jennifer L. Hope,Leticia G. Leon,Marjan van Meurs,Inge Brouwers-Haspels,Ruben Boers,Joachim Boers,Joost Gribnau,Wilfred F. J. van IJcken,Eric M.J. Bindels,Remco Hoogenboezem,Stefan J. Erkeland,Yvonne M. Mueller,Peter D. Katsikis +15 more
TL;DR: It is shown that repeat stimulation of purified TCR transgenic OT-I CTL with their specific peptide induces all the functional and phenotypic characteristics of exhaustion and Tcf7 promoter DNA methylation contributes to TCF1 downregulation in exhausted CTL.