Metabolic Instruction of Immunity
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TLDR
This review of immunometabolism will reference the most recent literature to cover the choices that environments impose on the metabolism and function of immune cells and highlight their consequences during homeostasis and disease.About:
This article is published in Cell.The article was published on 2017-05-04 and is currently open access. It has received 787 citations till now.read more
Citations
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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
Weimin Wang,Michael D. Green,Jae Eun Choi,Miguel Gijón,Paul D. Kennedy,Jeffrey K. Johnson,Peng Liao,Xueting Lang,Ilona Kryczek,Amanda Sell,Houjun Xia,Jiajia Zhou,Gaopeng Li,Jing Li,Wei Li,Shuang Wei,Linda Vatan,Hongjuan Zhang,Wojciech Szeliga,Wei Gu,Rebecca Liu,Theodore S. Lawrence,Candice Lamb,Yuri Tanno,Marcin Cieslik,Everett Stone,George Georgiou,Timothy A. Chan,Arul M. Chinnaiyan,Arul M. Chinnaiyan,Weiping Zou +30 more
TL;DR: Investigation of human transcriptomes before and during nivolumab therapy revealed that clinical benefits correlate with reduced expression of SLC3A2 and increased IFNγ and CD8 and targeting this pathway in combination with checkpoint blockade is a potential therapeutic approach.
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Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
Tamas Fulop,Anis Larbi,Gilles Dupuis,Aurélie Le Page,Eric Frost,Alan A. Cohen,Jacek M. Witkowski,Claudio Franceschi +7 more
TL;DR: Recent cumulative data suggest that, without the existence of the immunosenescence/inflamm-aging duo, human longevity would be greatly shortened and it may be more suitable to aim to maintain general homeostasis and function by appropriately improving immune-inflammatory-functions.
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Macrophages and Metabolism in the Tumor Microenvironment
TL;DR: The metabolic circuitries whereby TAMs condition the TME to support tumor growth and how such pathways can be therapeutically targeted are discussed.
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Mitochondrial metabolism and cancer.
Paolo E. Porporato,Nicoletta Filigheddu,José Manuel Bravo-San Pedro,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi +5 more
TL;DR: The cancer cell-intrinsic and cell-extrinsics mechanisms through which mitochondria influence all steps of oncogenesis are reviewed, with a focus on the therapeutic potential of targeting mitochondrial metabolism for cancer therapy.
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Tumor microenvironment complexity and therapeutic implications at a glance.
Roghayyeh Baghban,Leila Roshangar,Rana Jahanban-Esfahlan,Khaled Seidi,Abbas Ebrahimi-Kalan,Mehdi Jaymand,Saeed Kolahian,Tahereh Javaheri,Peyman Zare,Peyman Zare +9 more
TL;DR: This review evaluates the dynamic interactions of cancer cells with their microenvironment consisting of stromal cells and extracellular matrix components in various advanced cancer models, with a focus on 3D systems as well as lab-on-chip devices.
References
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Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
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The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
Patrick M. Smith,Michael R. Howitt,Nicolai Panikov,Monia Michaud,Carey Ann Gallini,Mohammad Bohlooly-Y,Jonathan N. Glickman,Wendy S. Garrett +7 more
TL;DR: This study determined that short-chain fatty acids, gut microbiota–derived bacterial fermentation products, regulate the size and function of the colonic Treg pool and protect against colitis in a Ffar2-dependent manner in mice, revealing that a class of abundant microbial metabolites underlies adaptive immune microbiota coadaptation and promotes colonic homeostasis and health.
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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,Takaho A. Endo,Gaku Nakato,Daisuke Takahashi,Yumiko Nakanishi,Chikako Uetake,Keiko Kato,Tamotsu Kato,Masumi Takahashi,Noriko N. Fukuda,Shinnosuke Murakami,Eiji Miyauchi,Shingo Hino,Koji Atarashi,Satoshi Onawa,Yumiko Fujimura,Trevor Lockett,Julie M. Clarke,David L. Topping,Masaru Tomita,Shohei Hori,Osamu Ohara,Tatsuya Morita,Haruhiko Koseki,Jun Kikuchi,Kenya Honda,Koji Hase,Hiroshi Ohno +29 more
TL;DR: It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Nicholas Arpaia,Clarissa Campbell,Xiying Fan,Stanislav Dikiy,Joris van der Veeken,Paul deRoos,Hui Liu,Justin R. Cross,Klaus Pfeffer,Paul J. Coffer,Alexander Y. Rudensky +10 more
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
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Molecular and cellular insights into T cell exhaustion
E. John Wherry,Makoto Kurachi +1 more
TL;DR: Recent advances that provide a clearer molecular understanding of T cell exhaustion are reviewed and reveal new therapeutic targets for persisting infections and cancer.