S
Serina Huang
Researcher at University of California, San Diego
Publications - 5
Citations - 128
Serina Huang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Epigenomics & Cell type. The author has an hindex of 4, co-authored 5 publications receiving 64 citations.
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Journal ArticleDOI
Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
Joshua Chiou,Chun Zeng,Zhang Cheng,Jee Yun Han,Michael Schlichting,Michael Miller,Robert Mendez,Serina Huang,Jinzhao Wang,Yinghui Sui,Allison Deogaygay,Mei-Lin Okino,Yunjiang Qiu,Ying Sun,Parul Kudtarkar,Rongxin Fang,Sebastian Preissl,Maike Sander,David U. Gorkin,David U. Gorkin,Kyle J. Gaulton +20 more
TL;DR: In this paper, single-cell ATAC-seq analysis of human pancreatic islet cells identifies different cell clusters and transcription factors that underlie lineage- and state-specific regulation and helps prioritize type 2 diabetes risk variants.
Posted ContentDOI
Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
Joshua Chiou,Chun Zeng,Zhang Cheng,Jee Yun Han,Michael Schlichting,Serina Huang,Jinzhao Wang,Yinghui Sui,Allison Deogaygay,Mei-Lin Okino,Yunjiang Qiu,Ying Sun,Parul Kudtarkar,Rongxin Fang,Sebastian Preissl,Maike Sander,David U. Gorkin,Kyle J. Gaulton +17 more
TL;DR: A cell type- and state-resolved map of gene regulation in human islets is provided, likely mechanisms of T2D risk at hundreds of loci are illuminated, and the power of single cell epigenomics for interpreting complex disease genetics is demonstrated.
Journal ArticleDOI
Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Joshua Chiou,Joshua Chiou,Ryan J Geusz,Mei-Lin Okino,Jee Yun Han,Michael Miller,Rebecca L. Melton,Elisha Beebe,Paola Benaglio,Serina Huang,Katha Korgaonkar,Sandra Heller,Alexander Kleger,Sebastian Preissl,David U. Gorkin,David U. Gorkin,Maike Sander,Kyle J. Gaulton +17 more
TL;DR: In this paper, a genome-wide association study of type 1 diabetes (T1D) using 520,580 samples, and the identification of candidate cis-regulatory elements (cCREs) in pancreas and peripheral blood mononuclear cells using single-nucleus assay for transposase-accessible chromatin with sequencing (snATAC-seq) of 131,554 nuclei.
Posted ContentDOI
Multi-omics profiling of Earth’s biomes reveals that microbial and metabolite composition are shaped by the environment
Justin P. Shaffer,Louis-Félix Nothias,Louis-Félix Nothias,Luke R. Thompson,Luke R. Thompson,Jon G. Sanders,Rodolfo A. Salido,Sneha P. Couvillion,Asker Daniel Brejnrod,Serina Huang,Franck Lejzerowicz,Holly L. Lutz,Qiyun Zhu,Cameron Martino,James T. Morton,Smruthi Karthikeyan,Mélissa Nothias-Esposito,Mélissa Nothias-Esposito,Kai Dührkop,Sebastian Böcker,Hyun-Woo Kim,Alexander A. Aksenov,Alexander A. Aksenov,Wout Bittremieux,Wout Bittremieux,Wout Bittremieux,Jeremiah J. Minich,Clarisse Marotz,Bryant Mm,Karenina Sanders,Tara Schwartz,Greg Humphrey,Vásquez-Baeza Y,Anupriya Tripathi,Anupriya Tripathi,Laxmi Parida,Anna Paola Carrieri,Niina Haiminen,Kristen L. Beck,Promi Das,A. Gonzalez,Daniel McDonald,Søren Michael Karst,Mads Albertsen,Gail Ackermann,Jeff DeReus,Torsten Thomas,Daniel Petras,Daniel Petras,Ashley Shade,James C. Stegen,Se Jin Song,Thomas O. Metz,Austin D. Swafford,Pieter C. Dorrestein,Pieter C. Dorrestein,Janet K. Jansson,Jack A. Gilbert,Rob Knight +58 more
TL;DR: In this paper, an integrated omics approach is used to describe the Earth's metabolome, which is a direct survey of metabolites associated with microbial communities spanning diverse environments using untargeted metabolomics coupled with metagenome analysis.
Posted ContentDOI
Large-scale genetic association and single cell accessible chromatin mapping defines cell type-specific mechanisms of type 1 diabetes risk
Joshua Chiou,Ryan J Geusz,Mei-Lin Okino,Jee Yun Han,Michael Miller,Paola Benaglio,Serina Huang,Katha Korgaonkar,Sandra Heller,Alexander Kleger,Sebastian Preissl,David U. Gorkin,Maike Sander,Kyle J. Gaulton +13 more
TL;DR: A role for the exocrine pancreas in T1D pathogenesis is supported and the power of combining large-scale GWAS and single cell epigenomics to provide insight into the cellular origins of complex disease is highlighted.