S
Seung Hoan Choi
Researcher at Broad Institute
Publications - 4
Citations - 2278
Seung Hoan Choi is an academic researcher from Broad Institute. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 4, co-authored 4 publications receiving 1348 citations.
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Journal ArticleDOI
Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
Amit Khera,Mark Chaffin,Krishna G. Aragam,Mary E. Haas,Carolina Roselli,Seung Hoan Choi,Pradeep Natarajan,Eric S. Lander,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor,Sekar Kathiresan +12 more
TL;DR: Genome-wide polygenic risk scores derived from GWAS data for five common diseases can identify subgroups of the population with risk approaching or exceeding that of a monogenic mutation.
Journal ArticleDOI
Transcriptional and Cellular Diversity of the Human Heart
Nathan R. Tucker,Mark Chaffin,Stephen J. Fleming,Amelia W. Hall,Victoria A. Parsons,Kenneth Bedi,Amer-Denis Akkad,Caroline N. Herndon,Alessandro Arduini,Irinna Papangeli,Carolina Roselli,François Aguet,Seung Hoan Choi,Kristin G. Ardlie,Mehrtash Babadi,Kenneth B. Margulies,Christian Stegmann,Patrick T. Ellinor +17 more
TL;DR: Using large-scale single nuclei RNA sequencing, the transcriptional and cellular diversity in the normal human heart was defined and the identification of discrete cell subtypes and differentially expressed genes within the heart will ultimately facilitate the development of new therapeutics for cardiovascular diseases.
Journal ArticleDOI
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Jonas B. Nielsen,Jonas B. Nielsen,Oren Rom,Ida Surakka,Sarah E. Graham,Wei Zhou,Tanmoy Roychowdhury,Lars G. Fritsche,Lars G. Fritsche,Sarah A Gagliano Taliun,Carlo Sidore,Yuhao Liu,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Brooke N. Wolford,William Overton,Ying Zhao,Jin Chen,He Zhang,Whitney E. Hornsby,Akua Acheampong,Austen Grooms,Amanda Schaefer,Gregory J.M. Zajac,Luis Villacorta,Jifeng Zhang,Ben Michael Brumpton,Mari Løset,Vivek Rai,Pia R. Lundegaard,Pia R. Lundegaard,Morten S. Olesen,Morten S. Olesen,Kent D. Taylor,Nicholette D. Palmer,Yii Der Chen,Seung Hoan Choi,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor,Kathleen C. Barnes,Michelle Daya,Nicholas Rafaels,Scott T. Weiss,Scott T. Weiss,Jessica Lasky-Su,Jessica Lasky-Su,Russell P. Tracy,Ramachandran S. Vasan,L. Adrienne Cupples,Rasika A. Mathias,Lisa R. Yanek,Lewis C. Becker,Patricia A. Peyser,Lawrence F. Bielak,Jennifer A. Smith,Stella Aslibekyan,Bertha Hidalgo,Donna K. Arnett,Marguerite R. Irvin,James G. Wilson,Solomon K. Musani,Adolfo Correa,Stephen S. Rich,Xiuqing Guo,Jerome I. Rotter,Barbara A. Konkle,Jill M. Johnsen,Allison E. Ashley-Koch,Marilyn J. Telen,Vivien A. Sheehan,John Blangero,Joanne E. Curran,Juan M. Peralta,Courtney G. Montgomery,Wayne Huey-Herng Sheu,Ren-Hua Chung,Karen Schwander,Seyed Mehdi Nouraie,Victor R. Gordeuk,Yingze Zhang,Charles Kooperberg,Alexander P. Reiner,Alexander P. Reiner,Rebecca D. Jackson,Eugene R. Bleecker,Deborah A. Meyers,Xingnan Li,Sayantan Das,Ketian Yu,Jonathon LeFaive,Albert V. Smith,Thomas W. Blackwell,Daniel Taliun,Sebastian Zöllner,Lukas Forer,Sebastian Schoenherr,Christian Fuchsberger,Anita Pandit,Matthew Zawistowski,Sachin Kheterpal,Chad M. Brummett,Pradeep Natarajan,Pradeep Natarajan,David Schlessinger,Seunggeun Lee,Hyun Min Kang,Francesco Cucca,Oddgeir L. Holmen,Bjørn Olav Åsvold,Michael Boehnke,Sekar Kathiresan,Sekar Kathiresan,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Y. Eugene Chen,Cristen J. Willer,Kristian Hveem,Kristian Hveem +119 more
TL;DR: In this article, the authors performed genome-wide analyses of participants in the HUNT Study in Norway to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function.
Posted ContentDOI
Transcriptional and Cellular Diversity of the Human Heart
Nathan R. Tucker,Nathan R. Tucker,Mark Chaffin,Stephen J. Fleming,Amelia W. Hall,Amelia W. Hall,Victoria A. Parsons,Kenneth Bedi,Amer-Denis Akkad,Amer-Denis Akkad,Caroline N. Herndon,Alessandro Arduini,Irinna Papangeli,Irinna Papangeli,Carolina Roselli,Carolina Roselli,François Aguet,Seung Hoan Choi,Kristin G. Ardlie,Mehrtash Babadi,Kenneth B. Margulies,Christian Stegmann,Christian Stegmann,Patrick T. Ellinor,Patrick T. Ellinor +24 more
TL;DR: Using large-scale single nuclei RNA sequencing, the transcriptional and cellular diversity in the normal human heart is defined and the identification of discrete cell subtypes and differentially expressed genes within the heart will ultimately facilitate the development of new therapeutics for cardiovascular diseases.