G
Gregory J.M. Zajac
Researcher at University of Michigan
Publications - 14
Citations - 212
Gregory J.M. Zajac is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 8, co-authored 12 publications receiving 111 citations. Previous affiliations of Gregory J.M. Zajac include Broad Institute.
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Journal ArticleDOI
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
Xiao Wang,Huimin Wang,Bolin Xu,Dong Huang,Chao Nie,Longjun Pu,Gregory J.M. Zajac,Han Yan,Jingru Zhao,Fangyuan Shi,Brian T. Emmer,Jia Lu,Rui Wang,Xiaohui Dong,Jianye Dai,Wenjing Zhou,Chu Wang,Ge Gao,Yan Wang,Cristen J. Willer,Xiangfeng Lu,Yuangang Zhu,Xiaowei Chen +22 more
TL;DR: These findings show that the pairing between SURF4 and SAR1B synergistically operates a specialized, dosage-sensitive transport program for circulating lipids, while further suggesting a potential translation to treat atherosclerosis and related cardio-metabolic diseases.
Journal ArticleDOI
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Jonas B. Nielsen,Jonas B. Nielsen,Oren Rom,Ida Surakka,Sarah E. Graham,Wei Zhou,Tanmoy Roychowdhury,Lars G. Fritsche,Lars G. Fritsche,Sarah A Gagliano Taliun,Carlo Sidore,Yuhao Liu,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Brooke N. Wolford,William Overton,Ying Zhao,Jin Chen,He Zhang,Whitney E. Hornsby,Akua Acheampong,Austen Grooms,Amanda Schaefer,Gregory J.M. Zajac,Luis Villacorta,Jifeng Zhang,Ben Michael Brumpton,Mari Løset,Vivek Rai,Pia R. Lundegaard,Pia R. Lundegaard,Morten S. Olesen,Morten S. Olesen,Kent D. Taylor,Nicholette D. Palmer,Yii Der Chen,Seung Hoan Choi,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor,Kathleen C. Barnes,Michelle Daya,Nicholas Rafaels,Scott T. Weiss,Scott T. Weiss,Jessica Lasky-Su,Jessica Lasky-Su,Russell P. Tracy,Ramachandran S. Vasan,L. Adrienne Cupples,Rasika A. Mathias,Lisa R. Yanek,Lewis C. Becker,Patricia A. Peyser,Lawrence F. Bielak,Jennifer A. Smith,Stella Aslibekyan,Bertha Hidalgo,Donna K. Arnett,Marguerite R. Irvin,James G. Wilson,Solomon K. Musani,Adolfo Correa,Stephen S. Rich,Xiuqing Guo,Jerome I. Rotter,Barbara A. Konkle,Jill M. Johnsen,Allison E. Ashley-Koch,Marilyn J. Telen,Vivien A. Sheehan,John Blangero,Joanne E. Curran,Juan M. Peralta,Courtney G. Montgomery,Wayne Huey-Herng Sheu,Ren-Hua Chung,Karen Schwander,Seyed Mehdi Nouraie,Victor R. Gordeuk,Yingze Zhang,Charles Kooperberg,Alexander P. Reiner,Alexander P. Reiner,Rebecca D. Jackson,Eugene R. Bleecker,Deborah A. Meyers,Xingnan Li,Sayantan Das,Ketian Yu,Jonathon LeFaive,Albert V. Smith,Thomas W. Blackwell,Daniel Taliun,Sebastian Zöllner,Lukas Forer,Sebastian Schoenherr,Christian Fuchsberger,Anita Pandit,Matthew Zawistowski,Sachin Kheterpal,Chad M. Brummett,Pradeep Natarajan,Pradeep Natarajan,David Schlessinger,Seunggeun Lee,Hyun Min Kang,Francesco Cucca,Oddgeir L. Holmen,Bjørn Olav Åsvold,Michael Boehnke,Sekar Kathiresan,Sekar Kathiresan,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Y. Eugene Chen,Cristen J. Willer,Kristian Hveem,Kristian Hveem +119 more
TL;DR: In this article, the authors performed genome-wide analyses of participants in the HUNT Study in Norway to search for protein-altering variants with beneficial impact on quantitative blood traits related to cardiovascular disease, but without detrimental impact on liver function.
Journal ArticleDOI
The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links
Yu Jiang,Sai Chen,Xingyan Wang,Mengzhen Liu,William G. Iacono,John K. Hewitt,John E. Hokanson,Kenneth Krauter,Markku Laakso,Kevin Li,Sharon M. Lutz,Matt McGue,Anita Pandit,Gregory J.M. Zajac,Michael Boehnke,Gonçalo R. Abecasis,Scott I. Vrieze,Bibo Jiang,Xiaowei Zhan,Dajiang J. Liu +19 more
TL;DR: This work showed that the joint modeling approach provided an unbiased estimate of genetic effects, greatly improved the power of single-variant association tests among methods that can properly estimate allele effects, and enhanced gene-level tests over existing approaches.
Journal ArticleDOI
Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism
Zhonggang Li,James A Votava,Gregory J.M. Zajac,Jenny N. Nguyen,Fernanda B. Leyva Jaimes,Sophia M. Ly,Jacqueline A. Brinkman,Marco De Giorgi,Sushma Kaul,Cara L Green,Samantha L. St. Clair,Sabrina L. Belisle,Julia M. Rios,David W. Nelson,Mary G. Sorci-Thomas,William R. Lagor,Dudley W. Lamming,Chi-Liang Eric Yen,Brian W. Parks +18 more
TL;DR: A systematic approach that integrates mouse liver co-expression networks with human lipid GWAS data to identify regulators of cholesterol and lipid metabolism is developed, pinpointing Sestrin1 as a causal gene associated with plasma cholesterol levels in humans.
Journal ArticleDOI
Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes
Yu Jiang,Sai Chen,Daniel McGuire,Fang Chen,Mengzhen Liu,William G. Iacono,John K. Hewitt,John E. Hokanson,Kenneth Krauter,Markku Laakso,Kevin Li,Sharon M. Lutz,Matt McGue,Anita Pandit,Gregory J.M. Zajac,Michael Boehnke,Gonçalo R. Abecasis,Scott I. Vrieze,Xiaowei Zhan,Bibo Jiang,Dajiang J. Liu +20 more
TL;DR: A method to combine summary statistics across participating studies and consistently estimate joint effects, even when the contributed summary statistics contain large amounts of missing values is developed.