M
M. Arfan Ikram
Researcher at Kaiser Permanente
Publications - 7
Citations - 650
M. Arfan Ikram is an academic researcher from Kaiser Permanente. The author has contributed to research in topics: Dementia & Cohort. The author has an hindex of 4, co-authored 7 publications receiving 458 citations. Previous affiliations of M. Arfan Ikram include Erasmus University Rotterdam & National Institutes of Health.
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Journal ArticleDOI
Novel genetic loci associated with hippocampal volume
Derrek P. Hibar,Hieab H.H. Adams,Neda Jahanshad,Ganesh Chauhan,Jason L. Stein,Jason L. Stein,Edith Hofer,Miguel E. Rentería,Joshua C. Bis,Alejandro Arias-Vasquez,M. Kamran Ikram,Sylvane Desrivières,Meike W. Vernooij,Lucija Abramovic,Saud Alhusaini,Saud Alhusaini,Najaf Amin,Micael Andersson,Konstantinos Arfanakis,Konstantinos Arfanakis,Benjamin S. Aribisala,Benjamin S. Aribisala,Nicola J. Armstrong,Nicola J. Armstrong,Lavinia Athanasiu,Tomas Axelsson,Ashley Beecham,Alexa S. Beiser,Alexa S. Beiser,Manon Bernard,Susan H. Blanton,Marc M. Bohlken,Marco P. Boks,Janita Bralten,Adam M. Brickman,Owen Carmichael,M. Mallar Chakravarty,M. Mallar Chakravarty,Qiang Chen,Christopher R.K. Ching,Christopher R.K. Ching,Vincent Chouraki,Vincent Chouraki,Vincent Chouraki,Gabriel Cuellar-Partida,Fabrice Crivello,Anouk den Braber,Nhat Trung Doan,Stefan Ehrlich,Stefan Ehrlich,Sudheer Giddaluru,Aaron Goldman,Rebecca F. Gottesman,Oliver Grimm,Michael Griswold,Tulio Guadalupe,Boris A. Gutman,Johanna Hass,Unn K. Haukvik,D. Hoehn,Avram J. Holmes,Avram J. Holmes,Martine Hoogman,Deborah Janowitz,Tianye Jia,Kjetil Nordbø Jørgensen,Nazanin Karbalai,Dalia Kasperaviciute,Dalia Kasperaviciute,Sungeun Kim,Marieke Klein,Bernd Kraemer,Phil Lee,Phil Lee,David C. Liewald,Lorna M. Lopez,Michelle Luciano,Christine Macare,Andre F. Marquand,Mar Matarin,Mar Matarin,Karen A. Mather,Manuel Mattheisen,Manuel Mattheisen,David R. McKay,Yuri Milaneschi,Susana Muñoz Maniega,Kwangsik Nho,Allison C. Nugent,Paul A. Nyquist,Loes M. Olde Loohuis,Jaap Oosterlaan,Martina Papmeyer,Martina Papmeyer,Lukas Pirpamer,Benno Pütz,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Jennifer S. Richards,Shannon L. Risacher,Roberto Roiz-Santiañez,Nanda Rommelse,Stefan Ropele,Emma J. Rose,Natalie A. Royle,Tatjana Rundek,Philipp G. Sämann,Arvin Saremi,Claudia L. Satizabal,Claudia L. Satizabal,Lianne Schmaal,Lianne Schmaal,Andrew J. Schork,Li Shen,Jean Shin,Elena Shumskaya,Albert V. Smith,Emma Sprooten,Emma Sprooten,Lachlan T. Strike,Lachlan T. Strike,Alexander Teumer,Diana Tordesillas-Gutiérrez,Roberto Toro,Daniah Trabzuni,Daniah Trabzuni,Stella Trompet,Dhananjay Vaidya,Jeroen van der Grond,Sven J. van der Lee,Dennis van der Meer,Marjolein M.J. van Donkelaar,Kristel R. van Eijk,Theo G.M. van Erp,Daan van Rooij,Daan van Rooij,Esther Walton,Esther Walton,Lars T. Westlye,Lars T. Westlye,Christopher D. Whelan,Christopher D. Whelan,Beverly G. Windham,Anderson M. Winkler,Anderson M. Winkler,Katharina Wittfeld,Katharina Wittfeld,Girma Woldehawariat,Christiane Wolf,Thomas Wolfers,Lisa R. Yanek,Jingyun Yang,Jingyun Yang,Alex P. Zijdenbos,Marcel P. Zwiers,Ingrid Agartz,Ingrid Agartz,Laura Almasy,Laura Almasy,Laura Almasy,D. Ames,D. Ames,Philippe Amouyel,Ole A. Andreassen,Sampath Arepalli,Amelia A. Assareh,Sandra Barral,Mark E. Bastin,Diane M. Becker,James T. Becker,David A. Bennett,David A. Bennett,John Blangero,Hans van Bokhoven,Dorret I. Boomsma,Henry Brodaty,Henry Brodaty,Rachel M. Brouwer,Han G. Brunner,Han G. Brunner,Randy L. Buckner,Randy L. Buckner,Jan K. Buitelaar,Kazima B. Bulayeva,Wiepke Cahn,Vince D. Calhoun,Dara M. Cannon,Dara M. Cannon,Gianpiero L. Cavalleri,Ching-Yu Cheng,Ching-Yu Cheng,Ching-Yu Cheng,Sven Cichon,Sven Cichon,Sven Cichon,M. R. Cookson,Aiden Corvin,Benedicto Crespo-Facorro,Joanne E. Curran,Michael Czisch,Anders M. Dale,Gareth E. Davies,Anton J. M. de Craen,Eco J. C. de Geus,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Greig I. de Zubicaray,Ian J. Deary,Stéphanie Debette,Stéphanie Debette,Stéphanie Debette,Charles C. DeCarli,Norman Delanty,Norman Delanty,Chantal Depondt,Anita L. DeStefano,Anita L. DeStefano,Allissa Dillman,Srdjan Djurovic,Srdjan Djurovic,G. Donohoe,G. Donohoe,Wayne C. Drevets,Wayne C. Drevets,Ravi Duggirala,Thomas D. Dyer,Christian Enzinger,Susanne Erk,Thomas Espeseth,Thomas Espeseth,Iryna O. Fedko,Guillén Fernández,Luigi Ferrucci,Simon E. Fisher,Simon E. Fisher,Debra A. Fleischman,Debra A. Fleischman,Ian Ford,Myriam Fornage,Tatiana Foroud,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Masaki Fukunaga,J. Raphael Gibbs,J. Raphael Gibbs,David C. Glahn,Randy L. Gollub,Harald H.H. Göring,Robert C. Green,Robert C. Green,Oliver Gruber,Vilmundur Gudnason,Sebastian Guelfi,Asta Håberg,Asta Håberg,Narelle K. Hansell,Narelle K. Hansell,John Hardy,Catharina A. Hartman,Ryota Hashimoto,Ryota Hashimoto,K Hegenscheid,Andreas Heinz,Stephanie Le Hellard,Dena G. Hernandez,Dena G. Hernandez,Dirk J. Heslenfeld,Beng-Choon Ho,Pieter J. Hoekstra,Wolfgang Hoffmann,Wolfgang Hoffmann,Albert Hofman,Florian Holsboer,Florian Holsboer,Georg Homuth,Norbert Hosten,Jouke-Jan Hottenga,Matthew J. Huentelman,Hilleke E. Hulshoff Pol,Masashi Ikeda,Clifford R. Jack,Mark Jenkinson,Robert Johnson,Erik G. Jönsson,Erik G. Jönsson,J. Wouter Jukema,René S. Kahn,Ryota Kanai,Ryota Kanai,Ryota Kanai,I. Kloszewska,David S. Knopman,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,Stephen M. Lawrie,Herve Lemaitre,Xinmin Liu,Xinmin Liu,Dan L. Longo,Oscar L. Lopez,Simon Lovestone,Simon Lovestone,Oliver Martinez,Jean-Luc Martinot,Venkata S. Mattay,Venkata S. Mattay,C. McDonald,Andrew M. McIntosh,Francis J. McMahon,Katie L. McMahon,P. Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Sebastian Mohnke,Grant W. Montgomery,D. Morris,Thomas H. Mosley,Thomas W. Mühleisen,Thomas W. Mühleisen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Michael A. Nalls,Matthias Nauck,Matthias Nauck,Thomas E. Nichols,Wiro J. Niessen,Wiro J. Niessen,Markus M. Nöthen,Markus M. Nöthen,Lars Nyberg,Kazutaka Ohi,Rene L. Olvera,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Zdenka Pausova,Brenda W.J.H. Penninx,G. Bruce Pike,G. Bruce Pike,Steven G. Potkin,Bruce M. Psaty,Simone Reppermund,Simone Reppermund,Marcella Rietschel,Joshua L. Roffman,Nina Romanczuk-Seiferth,Jerome I. Rotter,Mina Ryten,Mina Ryten,Ralph L. Sacco,Ralph L. Sacco,Perminder S. Sachdev,Perminder S. Sachdev,Andrew J. Saykin,Andrew J. Saykin,Reinhold Schmidt,Helena Schmidt,Peter R. Schofield,Peter R. Schofield,Sigurdur Sigursson,Andrew Simmons,Andrew Simmons,Andrew Singleton,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Hilkka Soininen,Hilkka Soininen,Vidar M. Steen,David J. Stott,Jessika E. Sussmann,Anbupalam Thalamuthu,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Magda Tsolaki,Christophe Tzourio,Christophe Tzourio,Andre G. Uitterlinden,Andre G. Uitterlinden,Maria del C. Valdés Hernández,Marcel Van Der Brug,Aad van der Lugt,Nic J.A. van der Wee,Neeltje E.M. van Haren,Dennis van 't Ent,Marie-José van Tol,Badri N. Vardarajan,Bruno Vellas,Dick J. Veltman,Henry Völzke,Henrik Walter,Joanna M. Wardlaw,Thomas H. Wassink,Michael E. Weale,Daniel R. Weinberger,Michael Weiner,Wei Wen,Wei Wen,Eric Westman,Tonya White,Tonya White,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Clinton B. Wright,Clinton B. Wright,Ronald H. Zielke,Alan B. Zonderman,Nicholas G. Martin,Cornelia M. van Duijn,Margaret J. Wright,Margaret J. Wright,William T. Longstreth,Gunter Schumann,Hans J. Grabe,Barbara Franke,Lenore J. Launer,Sarah E. Medland,Sudha Seshadri,Sudha Seshadri,Paul M. Thompson,M. Arfan Ikram,M. Arfan Ikram +432 more
TL;DR: It is shown that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155), and these findings suggest novel biological pathways through which human genetic variation influences hippocampus volume and risk for neuropsychiatric illness.
Journal ArticleDOI
Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Frank J. Wolters,Frank J. Wolters,Lori B. Chibnik,Reem Waziry,Roy M. Anderson,Claudine Berr,Alexa S. Beiser,Joshua C. Bis,Deborah Blacker,Daniel Bos,Daniel Bos,Carol Brayne,Jean-François Dartigues,Sirwan K.L. Darweesh,Kendra Davis-Plourde,Frank de Wolf,Stéphanie Debette,Carole Dufouil,Myriam Fornage,Jaap Goudsmit,Leslie Grasset,Vilmundur Gudnason,Christoforos Hadjichrysanthou,Catherine Helmer,M. Arfan Ikram,M. Kamran Ikram,Erik Joas,Silke Kern,Lewis H. Kuller,Lenore J. Launer,Oscar L. Lopez,Fiona E. Matthews,Kevin McRae-McKee,Osorio Meirelles,Thomas H. Mosley,Matthew P. Pase,Bruce M. Psaty,Bruce M. Psaty,Claudia L. Satizabal,Claudia L. Satizabal,Sudha Seshadri,Sudha Seshadri,Ingmar Skoog,Blossom C. M. Stephan,Hanna Wetterberg,Mei Mei Wong,Anna Zettergren,Albert Hofman,Albert Hofman +48 more
TL;DR: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies, and somewhat more pronouncedly in men than in women.
The potential for prevention of dementia across two decades: the prospective, population-based
Michiel J. Bos,Marileen L.P. Portegies,Albert Hofman,Oscar H. Franco,Peter J. Koudstaal,M. Arfan Ikram +5 more
TL;DR: In this paper, the authors provided contemporary estimates of the proportion of dementia cases that could be prevented if modifiable risk factors were eliminated, i.e., population attributable risk (PAR), and studied whether the PAR has changed across the last two decades.
Featured Article Trajectories of decline in cognition and daily functioning in preclinical dementia
Vincentius J.A. Verlinden,Jos N. van der Geest,Renée F A G de Bruijn,Albert Hofman,Peter J. Koudstaal,M. Arfan Ikram +5 more
TL;DR: Investigation of trajectories of cognition and daily functioning in preclinical dementia, during 18 years of follow‐up, finds clear trends in decline in cognition and day-to-day functioning.
Genetic,Physiological,andLifestylePredictorsof MortalityintheGeneralPopulation
Stefan Walter,Johan P. Mackenbach,Zoltán Vokó,Stefan K. Lhachimi,M. Arfan Ikram,Anne B. Newman,Joanne M. Murabito,Melissa E. Garcia,Vilmundur Gudnason,Toshiko Tanaka,Gregory J. Tranah,Henri Wallaschofski,Thomas D. Kocher,Lenore J. Launer,Nora Franceschini,Maarten Schipper,Albert Hofman,Henning Tiemeier +17 more
TL;DR: Mortality can be predicted reasonably well over a long period, and genetic factors independently predict mortality, but only modestly more than other risk indicators.