M
Michele M. Doody
Researcher at National Institutes of Health
Publications - 111
Citations - 10554
Michele M. Doody is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 49, co-authored 111 publications receiving 9846 citations. Previous affiliations of Michele M. Doody include United States Department of Health and Human Services.
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Journal ArticleDOI
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton,Karen A. Pooley,Alison M. Dunning,Paul D.P. Pharoah,Deborah J. Thompson,Dennis G. Ballinger,Jeffery P. Struewing,Jonathan J. Morrison,Helen I. Field,Robert Luben,Nicholas J. Wareham,Shahana Ahmed,Catherine S. Healey,Richard Bowman,Kerstin B. Meyer,Christopher A. Haiman,Laurence K. Kolonel,Brian E. Henderson,Loic Le Marchand,Paul Brennan,Suleeporn Sangrajrang,Valerie Gaborieau,Fabrice Odefrey,Chen-Yang Shen,Pei-Ei Wu,Hui-Chun Wang,Diana Eccles,D. Gareth Evans,Julian Peto,Olivia Fletcher,Nichola Johnson,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Montserrat Garcia-Closas,Louise A. Brinton,Stephen J. Chanock,Jolanta Lissowska,Beata Peplonska,Heli Nevanlinna,Rainer Fagerholm,H Eerola,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Sei Hyun Ahn,David J. Hunter,Susan E. Hankinson,David G. Cox,Per Hall,Sara Wedrén,Jianjun Liu,Yen-Ling Low,Natalia Bogdanova,Peter Schu¨rmann,Do¨rk Do¨rk,Rob A. E. M. Tollenaar,Catharina E. Jacobi,Peter Devilee,Jan G. M. Klijn,Alice J. Sigurdson,Michele M. Doody,Bruce H. Alexander,Jinghui Zhang,Angela Cox,Ian W. Brock,Gordon MacPherson,Malcolm W.R. Reed,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,André G. Uitterlinden,Fernando Rivadeneira,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,John L. Hopper,Margaret R. E. McCredie,Margaret R. E. McCredie,Margaret R. E. McCredie,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Chris Schroen,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Yon-Dschun Ko,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,_ kConFab,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Nicholas E. Day,David Cox,Bruce A.J. Ponder +109 more
TL;DR: To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
Journal ArticleDOI
Breast cancer mortality after diagnostic radiography: findings from the U.S. Scoliosis Cohort Study.
Michele M. Doody,John E. Lonstein,Marilyn Stovall,David G. Hacker,Nickolas Luckyanov,Charles E. Land +5 more
TL;DR: It is suggested that exposure to multiple diagnostic radiographic examinations during childhood and adolescence may increase the risk of breast cancer among women with scoliosis; however, potential confounding between radiation dose and severity of disease and thus with reproductive history may explain some of the increased risk observed.
Journal ArticleDOI
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
Gilles Thomas,Kevin B. Jacobs,Kevin B. Jacobs,Peter Kraft,Meredith Yeager,Meredith Yeager,Sholom Wacholder,David G. Cox,David G. Cox,Susan E. Hankinson,Amy Hutchinson,Amy Hutchinson,Zhaoming Wang,Zhaoming Wang,Kai Yu,Nilanjan Chatterjee,Montserrat Garcia-Closas,Jesus Gonzalez-Bosquet,Ludmila Prokunina-Olsson,Nick Orr,Walter C. Willett,Walter C. Willett,Graham A. Colditz,Regina G. Ziegler,Christine D. Berg,Saundra S. Buys,Catherine A. McCarty,Heather Spencer Feigelson,Eugenia E. Calle,Michael J. Thun,Ryan Diver,Ross L. Prentice,Rebecca D. Jackson,Charles Kooperberg,Rowan T. Chlebowski,Jolanta Lissowska,Beata Peplonska,Louise A. Brinton,Alice J. Sigurdson,Michele M. Doody,Parveen Bhatti,Bruce H. Alexander,Julie E. Buring,I-Min Lee,Lars J. Vatten,Kristian Hveem,Merethe Kumle,Richard B. Hayes,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,Stephen J. Chanock,David J. Hunter +53 more
TL;DR: A three-stage genome-wide association study of breast cancer in 9,770 cases and 10,799 controls in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative confirmed associations with loci on chromosomes 2q35, 5p12, 5q11.2, 8q24, 10q26 and 16q12.1.
Journal ArticleDOI
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Shahana Ahmed,Gilles Thomas,Maya Ghoussaini,Catherine S. Healey,Manjeet K. Humphreys,Radka Platte,Jonathan J. Morrison,Melanie Maranian,Karen A. Pooley,Robert Luben,Diana Eccles,D. Gareth Evans,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Julian Peto,Michael R. Stratton,Nazneen Rahman,Kevin B. Jacobs,Kevin B. Jacobs,Ross L. Prentice,Garnet L. Anderson,Aleksandar Rajkovic,J. David Curb,Regina G. Ziegler,Christine D. Berg,Saundra S. Buys,Catherine A. McCarty,Heather Spencer Feigelson,Eugenia E. Calle,Michael J. Thun,W. Ryan Diver,Stig E. Bojesen,Børge G. Nordestgaard,Henrik Flyger,Thilo Dörk,Peter Schürmann,Peter Hillemanns,Johann H. Karstens,Natalia Bogdanova,Natalia Antonenkova,Iosif V. Zalutsky,Marina Bermisheva,S. A. Fedorova,Elza Khusnutdinova,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Sei Hyun Ahn,Peter Devilee,Christi J. van Asperen,R.A.E.M. Tollenaar,Caroline Seynaeve,Montserrat Garcia-Closas,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Heli Nevanlinna,Tuomas Heikkinen,Kristiina Aittomäki,Carl Blomqvist,John L. Hopper,Melissa C. Southey,Letitia D. Smith,Amanda B. Spurdle,Marjanka K. Schmidt,Annegien Broeks,Richard van Hien,Sten Cornelissen,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,Rita K. Schmutzler,Barbara Burwinkel,Barbara Burwinkel,Claus R. Bartram,Alfons Meindl,Hiltrud Brauch,Hiltrud Brauch,Christina Justenhoven,Christina Justenhoven,Ute Hamann,Jenny Chang-Claude,Rebecca Hein,Shan Wang-Gohrke,Annika Lindblom,Sara Margolin,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Janet E. Olson,Xianshu Wang,Zachary S. Fredericksen,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Dallas R. English,Dallas R. English,Susan E. Hankinson,David G. Cox,Peter Kraft,Lars J. Vatten,Kristian Hveem,Merethe Kumle,Alice J. Sigurdson,Michele M. Doody,Parveen Bhatti,Bruce H. Alexander,Maartje J. Hooning,Ans M.W. van den Ouweland,Rogier A. Oldenburg,Mieke Schutte,Per Hall,Kamila Czene,Jianjun Liu,Yuqing Li,Angela Cox,Graeme Elliott,Ian W. Brock,Malcolm W.R. Reed,Chen-Yang Shen,Chen-Yang Shen,Jyh Cherng Yu,Giu Cheng Hsu,Shou Tung Chen,Hoda Anton-Culver,Argyrios Ziogas,Irene L. Andrulis,Julia A. Knight,Jonathan Beesley,Ellen L. Goode,Fergus J. Couch,Georgia Chenevix-Trench,Robert N. Hoover,Bruce A.J. Ponder,Bruce A.J. Ponder,David J. Hunter,Paul D.P. Pharoah,Alison M. Dunning,Stephen J. Chanock,Douglas F. Easton +144 more
TL;DR: Strong evidence is found for additional susceptibility loci on 3p and 17q and potential causative genes include SLC4A7 and NEK10 on3p and COX11 on 17q.
Journal ArticleDOI
Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics
Montserrat Garcia-Closas,Per Hall,Heli Nevanlinna,Karen A. Pooley,Jonathan J. Morrison,Douglas A. Richesson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,José Ignacio Arias,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,P. Zamora,Hiltrud Brauch,Hiltrud Brauch,Christina Justenhoven,Christina Justenhoven,Ute Hamann,Yon Ko,Thomas Bruening,Susanne Haas,Thilo Dörk,Peter Schürmann,Peter Hillemanns,Natalia Bogdanova,Michael Bremer,Johann H. Karstens,Rainer Fagerholm,Kirsimari Aaltonen,Kristiina Aittomäki,Karl von Smitten,Carl Blomqvist,Arto Mannermaa,Matti Uusitupa,Matti Eskelinen,Maria Tengström,Veli-Matti Kosma,V. Kataja,Georgia Chenevix-Trench,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,Peter Devilee,Christi J. van Asperen,Catharina E. Jacobi,Rob A. E. M. Tollenaar,Petra E A Huijts,Jan G. M. Klijn,Jenny Chang-Claude,Silke Kropp,Tracy Slanger,Dieter Flesch-Janys,Elke Mutschelknauss,Ramona Salazar,Shan Wang-Gohrke,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Celine M. Vachon,Zachary S. Fredericksen,Graham G. Giles,Laura Baglietto,Gianluca Severi,John L. Hopper,Dallas R. English,Melissa C. Southey,Christopher A. Haiman,Brian E. Henderson,Laurence N. Kolonel,Loic Le Marchand,Daniel O. Stram,David J. Hunter,Susan E. Hankinson,David G. Cox,Rulla M. Tamimi,Peter Kraft,Mark E. Sherman,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Maartje J. Hooning,Han Meijers-Heijboer,J. Margriet Collée,Ans M.W. van den Ouweland,André G. Uitterlinden,Jianjun Liu,Yen Lin Low,Li Yuqing,Keith Humphreys,Kamila Czene,Angela Cox,Sabapathy P. Balasubramanian,Simon S. Cross,Malcolm W.R. Reed,Fiona M. Blows,Kristy Driver,Alison M. Dunning,Jonathan Tyrer,Bruce A.J. Ponder,Suleeporn Sangrajrang,Paul Brennan,James McKay,Fabrice Odefrey,Valerie Gabrieau,Alice J. Sigurdson,Michele M. Doody,J. P. Struewing,Bruce H. Alexander,Douglas F. Easton,Paul D.P. Pharoah +112 more
TL;DR: The findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct.