C
Christina A. Markunas
Researcher at Research Triangle Park
Publications - 21
Citations - 1753
Christina A. Markunas is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Pregnancy & Genome-wide association study. The author has an hindex of 12, co-authored 21 publications receiving 1404 citations. Previous affiliations of Christina A. Markunas include United States Department of Health and Human Services & Duke University.
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Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
Journal ArticleDOI
Genomic and epigenetic evidence for oxytocin receptor deficiency in autism.
Simon G. Gregory,Jessica J. Connelly,Aaron J. Towers,Jessica S. Johnson,Dhani Biscocho,Christina A. Markunas,Carla Lintas,Ruth K. Abramson,Harry H. Wright,Peter R. Ellis,Cordelia Langford,Gordon Worley,G Robert Delong,Susan K. Murphy,Michael L. Cuccaro,Antonello Persico,Margaret A. Pericak-Vance +16 more
TL;DR: High-resolution genome-wide tilepath microarrays and comparative genomic hybridization are used to identify copy number variants within 119 probands from multiplex autism families to implicate the epigenetic regulation of OXTR in the development of the disorder and provide further evidence for the role of OxTR and the oxytocin signaling pathway.
Journal ArticleDOI
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence.
Dana B. Hancock,Yuelong Guo,Gunnar W Reginsson,Nathan C. Gaddis,Sharon M. Lutz,Richard Sherva,Anu Loukola,Camelia C. Minică,Christina A. Markunas,Younghun Han,Kendra A. Young,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Fangyi Gu,Daniel W. McNeil,Beenish Qaiser,Cristie Glasheen,S. Olson,M. T. Landi,P. A. F. Madden,Lindsay A. Farrer,Jacqueline M. Vink,Jacqueline M. Vink,Nancy L. Saccone,Michael C. Neale,Henry R. Kranzler,Henry R. Kranzler,James McKay,Rayjean J. Hung,Christopher I. Amos,Mary L. Marazita,Dorret I. Boomsma,Timothy B. Baker,Joel Gelernter,Jaakko Kaprio,Neil E. Caporaso,Thorgeir E. Thorgeirsson,John E. Hokanson,Laura J. Bierut,Kari Stefansson,Eric O. Johnson +40 more
TL;DR: The well-known CHRNA5-CHRNA3-CHRNB4 genes were reconfirmed and a novel association in the DNA methyltransferase gene DNMT3B yielded, which highlights the importance of genetically influenced regulation in brain on the risks of nicotine dependence, heavy smoking and consequent lung cancer.
Journal ArticleDOI
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Bryan C. Quach,Michael J. Bray,Nathan C. Gaddis,Mengzhen Liu,Teemu Palviainen,Camelia C. Minică,Stephanie Zellers,Richard Sherva,Fazil Aliev,Fazil Aliev,Michael Nothnagel,Kendra A. Young,Jesse Marks,Hannah Young,Megan U. Carnes,Yuelong Guo,Alex Waldrop,Nancy Y A Sey,M. T. Landi,Daniel W. McNeil,Dmitriy Drichel,Lindsay A. Farrer,Christina A. Markunas,Jacqueline M. Vink,Jouke-Jan Hottenga,William G. Iacono,Henry R. Kranzler,Henry R. Kranzler,Nancy L. Saccone,Michael C. Neale,Pamela A. F. Madden,Marcella Rietschel,Mary L. Marazita,Matt McGue,Hyejung Won,Georg Winterer,Richard A. Grucza,Danielle M. Dick,Joel Gelernter,Neil E. Caporaso,Timothy B. Baker,Dorret I. Boomsma,Jaakko Kaprio,John E. Hokanson,Scott I. Vrieze,Laura J. Bierut,Eric O. Johnson,Dana B. Hancock +47 more
TL;DR: The results highlight nicotine dependence-specific loci, emphasizing the FTND as a composite phenotype that expands genetic knowledge of smoking, and highlight the heaviness of smoking index.
Journal ArticleDOI
Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis
Jessica J. Connelly,Olga A. Cherepanova,Jennifer F. Doss,Themistoclis Karaoli,Travis S. Lillard,Christina A. Markunas,Sarah C. Nelson,Tianyuan Wang,Peter D. Ellis,Cordelia Langford,Carol Haynes,David Seo,Pascal J. Goldschmidt-Clermont,Svati H. Shah,Svati H. Shah,William E. Kraus,William E. Kraus,Elizabeth R. Hauser,Elizabeth R. Hauser,Simon G. Gregory +19 more
TL;DR: Hypomethylated genes, such as COL15A1, provide evidence for concomitant epigenetic regulation and genetic susceptibility, and define a class of causal targets that sit at the intersection of genetic and epigenetic predisposition in the etiology of complex disease.