L
Laurence P. Clarke
Researcher at National Institutes of Health
Publications - 31
Citations - 4231
Laurence P. Clarke is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Context (language use). The author has an hindex of 20, co-authored 31 publications receiving 3250 citations.
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Journal ArticleDOI
The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): a completed reference database of lung nodules on CT scans.
Samuel G. Armato,Geoffrey McLennan,Luc Bidaut,Michael F. McNitt-Gray,Charles R. Meyer,Anthony P. Reeves,Binsheng Zhao,Denise R. Aberle,Claudia I. Henschke,Eric A. Hoffman,Ella A. Kazerooni,Heber MacMahon,Edwin J. R. van Beek,David F. Yankelevitz,Alberto Biancardi,Peyton H. Bland,Matthew S. Brown,Roger Engelmann,Gary E. Laderach,Daniel Max,Richard C. Pais,David Qing,Rachael Y. Roberts,Amanda R. Smith,Adam Starkey,Poonam Batra,Philip Caligiuri,Ali Farooqi,Gregory W. Gladish,C. Matilda Jude,Reginald F. Munden,Iva Petkovska,Leslie E. Quint,Lawrence H. Schwartz,Baskaran Sundaram,Lori E. Dodd,Charles Fenimore,David Gur,Nicholas Petrick,John Freymann,Justin Kirby,Brian Hughes,Alessi Vande Casteele,Sangeeta Gupte,Maha Sallam,Michael D. Heath,Michael Kuhn,Ekta Dharaiya,Richard Burns,David Fryd,Marcos Salganicoff,Vikram Anand,Uri Shreter,Stephen Vastagh,Barbara Y. Croft,Laurence P. Clarke +55 more
TL;DR: The goal of this process was to identify as completely as possible all lung nodules in each CT scan without requiring forced consensus and is expected to provide an essential medical imaging research resource to spur CAD development, validation, and dissemination in clinical practice.
Journal ArticleDOI
Imaging biomarker roadmap for cancer studies.
James P B O'Connor,Eric O. Aboagye,Judith E. Adams,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Sally F. Barrington,Ambros J. Beer,Ronald Boellaard,Sarah E. Bohndiek,J. Michael Brady,Gina Brown,David L. Buckley,Thomas L. Chenevert,Laurence P. Clarke,Sandra Collette,Gary Cook,Nandita M. deSouza,John Dickson,Caroline Dive,Jeffrey L. Evelhoch,Corinne Faivre-Finn,Ferdia A. Gallagher,Fiona J. Gilbert,Robert J. Gillies,Vicky Goh,John R. Griffiths,Ashley M. Groves,Steve Halligan,Adrian L. Harris,David J. Hawkes,Otto S. Hoekstra,Erich P. Huang,Brian Hutton,Edward F. Jackson,Gordon C Jayson,Andrew J. I. Jones,Dow-Mu Koh,Denis Lacombe,Philippe Lambin,Nathalie Lassau,Martin O. Leach,Ting-Yim Lee,Edward Leen,Jason S. Lewis,Yan Liu,Mark F. Lythgoe,Prakash Manoharan,Ross J. Maxwell,Kenneth A. Miles,Bruno Morgan,Steve Morris,Tony Ng,Anwar R. Padhani,Geoff J M Parker,Mike Partridge,Arvind P. Pathak,Arvind P. Pathak,Andrew C. Peet,Shonit Punwani,Andrew R. Reynolds,Simon P. Robinson,Lalitha K. Shankar,Ricky A. Sharma,Dmitry Soloviev,Sigrid Stroobants,Daniel C. Sullivan,Stuart A. Taylor,Paul S. Tofts,Gillian M. Tozer,Marcel van Herk,Simon Walker-Samuel,James Wason,Kaye J. Williams,Paul Workman,Thomas E. Yankeelov,Kevin M. Brindle,Lisa M. McShane,Alan Jackson,John C. Waterton +78 more
TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.
Journal ArticleDOI
The Lung Image Database Consortium (LIDC) Data Collection Process for Nodule Detection and Annotation
Michael F. McNitt-Gray,Samuel G. Armato,Charles R. Meyer,Anthony P. Reeves,Geoffrey McLennan,Richie C. Pais,John Freymann,John Freymann,Matthew S. Brown,Roger Engelmann,Peyton H. Bland,Gary E. Laderach,Chris Piker,Junfeng Guo,Zaid J. Towfic,David Qing,David F. Yankelevitz,Denise R. Aberle,Edwin J. R. van Beek,Heber MacMahon,Ella A. Kazerooni,Barbara Y. Croft,Laurence P. Clarke +22 more
TL;DR: A unique data collection process was developed, tested, and implemented that allowed multiple readers at distributed sites to asynchronously review CT scans multiple times and captured the opinions of each reader regarding the location and spatial extent of lung nodules.
Journal ArticleDOI
Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging
Martin O. Leach,Bruno Morgan,Paul S. Tofts,David L. Buckley,Wei Huang,Mark A. Horsfield,Thomas L. Chenevert,David J. Collins,Alan Jackson,David A. Lomas,Brandon Whitcher,Laurence P. Clarke,Ruth Plummer,Ian Judson,Robert Jones,Roberto Alonzi,Thomas Brunner,Dow-Mu Koh,Philip S. Murphy,John C. Waterton,G. J. Parker,Martin J. Graves,Tom W. J. Scheenen,Thomas William Redpath,Matthew R. Orton,Gregory S. Karczmar,Henkjan J. Huisman,J.O. Barentsz,Anwar R. Padhani +28 more
TL;DR: In this article, a workshop was held to review the current status of DCE-MRI and to provide recommendations on how the technique can best be used for early stage clinical trials.
Journal ArticleDOI
The Lung Image Database Consortium (LIDC): a comparison of different size metrics for pulmonary nodule measurements
Anthony P. Reeves,Alberto Biancardi,Tatiyana V. Apanasovich,Charles R. Meyer,Heber MacMahon,Edwin J. R. van Beek,Ella A. Kazerooni,David F. Yankelevitz,Michael F. McNitt-Gray,Geoffrey McLennan,Samuel G. Armato,Claudia I. Henschke,Denise R. Aberle,Barbara Y. Croft,Laurence P. Clarke +14 more
TL;DR: The selection of data subsets for performance evaluation is highly impacted by the size metric choice, which is intended to facilitate the selection of unique repeatable size limited nodule subsets.