S
Steffen Stenger
Researcher at University of Ulm
Publications - 134
Citations - 14900
Steffen Stenger is an academic researcher from University of Ulm. The author has contributed to research in topics: Mycobacterium tuberculosis & Immune system. The author has an hindex of 46, co-authored 119 publications receiving 13155 citations. Previous affiliations of Steffen Stenger include University of Erlangen-Nuremberg & University of California.
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Journal ArticleDOI
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more
TL;DR: The data support a link between TLRs and vitamin D–mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Journal ArticleDOI
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger,Dennis A. Hanson,Rachel Teitelbaum,Puneet Dewan,Kayvan Niazi,Christopher J. Froelich,Tomas Ganz,Sybille Thoma-Uszynski,Agustı́n Melián,Christian Bogdan,Steven A. Porcelli,Barry R. Bloom,Alan M. Krensky,Robert L. Modlin +13 more
TL;DR: The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intrACEllular pathogens.
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Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin
TL;DR: It is demonstrated that cathelicidin is required for the 1,25D3-triggered antimicrobial activity against intracellular M. tuberculosis.
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Induction of Direct Antimicrobial Activity Through Mammalian Toll-Like Receptors
Sybille Thoma-Uszynski,Steffen Stenger,Osamu Takeuchi,Maria Teresa Ochoa,Matthias Engele,Peter A. Sieling,Peter F. Barnes,Martin Röllinghoff,Pal L. Bölcskei,Manfred Wagner,Shizuo Akira,Michael V. Norgard,John T. Belisle,Paul J. Godowski,Barry R. Bloom,Robert L. Modlin +15 more
TL;DR: It is shown that TLR2 activation leads to killing of intracellular Mycobacterium (M.) tuberculosis in both mouse and human macrophages, providing evidence that mammalian TLRs have retained not only the structural features of Drosophila Toll that allow them to respond to microbial ligands, but also the ability directly to activate antimicrobial effector pathways at the site of infection.
Journal ArticleDOI
Differential effects of cytolytic T cell subsets on intracellular infection
Steffen Stenger,Richard J. Mazzaccaro,Koichi Uyemura,Sungae Cho,Peter F. Barnes,Jean Pierre Rosat,Alessandro Sette,Michael B. Brenner,Steven A. Porcelli,Barry R. Bloom,Robert L. Modlin +10 more
TL;DR: The data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.