Sverre E. Kjeldsen

TL;DR: There was no difference in blood pressure reduction when comparing the losartan and candesartan groups during follow-up suggesting that other mechanisms related to different pharmacological properties of the drugs may explain the divergent clinical outcomes.

TL;DR: A positive association between the appearance of peripheral structural vascular changes as quantified through a hemodynamic technique and insulin resistance in young men with borderline elevation of blood pressure is shown.

TL;DR: In this article, the Losartan intervention for endpoint reduction in hypertension study, a double-blind, randomized (losartan versus atenolol) parallel-group study, including 9193 patients with hypertension and electrocardiographic left ventricular hypertrophy, showed that PP was the strongest single blood pressure predictor of new-onset AF determined by the decrease in the -2 Log likelihood statistic.

TL;DR: The present results suggest a relationship between increased vagal tone, high stroke volumes and incident AF, and particularly so in physically fit men.

TL;DR: Higher in-treatment HR on serial ECGs is associated with an increased likelihood of new-onset AF, independent of treatment modality, blood pressure lowering, and regression of ECG left ventricular hypertrophy in patients with essential hypertension.