T
Taras Makhnevych
Researcher at University of Toronto
Publications - 19
Citations - 3335
Taras Makhnevych is an academic researcher from University of Toronto. The author has contributed to research in topics: Nuclear pore & Nuclear transport. The author has an hindex of 16, co-authored 19 publications receiving 3133 citations. Previous affiliations of Taras Makhnevych include University of Alberta.
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Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
Journal ArticleDOI
The role of Hsp90 in protein complex assembly
Taras Makhnevych,Walid A. Houry +1 more
TL;DR: The effect of the chaperone on the assembly of the following seven complexes is discussed in this review: snoRNP, RNA polymerase II, phosphatidylinositol-3 kinase-related protein kinase (PIKK), telomere complex, kinetochore, RNA induced silencing complexes (RISC), and 26S proteasome.
Journal ArticleDOI
Cell cycle regulated transport controlled by alterations in the nuclear pore complex.
TL;DR: It is proposed that fluctuations in Kap121p transport mediated by the NPC contribute to controlling the subcellular distribution of molecules that direct progression through mitosis.
Journal ArticleDOI
Global map of SUMO function revealed by protein-protein interaction and genetic networks.
Taras Makhnevych,Yaroslav Sydorskyy,Yaroslav Sydorskyy,Xiaofeng Xin,Tharan Srikumar,Tharan Srikumar,Franco J. Vizeacoumar,Stanley M. Jeram,Stanley M. Jeram,Zhijian Li,Sondra Bahr,Brenda J. Andrews,Charles Boone,Brian Raught,Brian Raught +14 more
TL;DR: Roles for the SUMO system are identified in the function of the AAA ATPase Cdc48p, the regulation of lipid metabolism, localization of the ATP-dependent endonuclease Dna2p, and recovery from the DNA-damage checkpoint.
Journal ArticleDOI
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Franco J. Vizeacoumar,Franco J. Vizeacoumar,Roland Arnold,Frederick S. Vizeacoumar,Megha Chandrashekhar,Alla Buzina,Jordan T.F. Young,Jordan T.F. Young,Julian H. M. Kwan,Azin Sayad,Patricia Mero,Steffen Lawo,Steffen Lawo,Hiromasa Tanaka,Kevin R. Brown,Anastasia Baryshnikova,Anthony B. Mak,Yaroslav Fedyshyn,Yadong Wang,Glauber C. Brito,Dahlia Kasimer,Taras Makhnevych,Troy Ketela,Alessandro Datti,Mohan Babu,Andrew Emili,Laurence Pelletier,Laurence Pelletier,Jeff Wrana,Jeff Wrana,Zev A. Wainberg,Philip M. Kim,Robert Rottapel,Robert Rottapel,Robert Rottapel,Catherine A. O’Brien,Catherine A. O’Brien,Brenda J. Andrews,Charles Boone,Jason Moffat +39 more
TL;DR: The reference network suggests that many cancer vulnerabilities remain to be discovered through systematic derivation of a network of differentially essential genes in an isogenic cancer cell model.