T
Thomas Foltynie
Researcher at UCL Institute of Neurology
Publications - 381
Citations - 26959
Thomas Foltynie is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 80, co-authored 352 publications receiving 21023 citations. Previous affiliations of Thomas Foltynie include University College London & University of Kent.
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Journal ArticleDOI
The Effect of Short Pulse Width Settings on the Therapeutic Window in Subthalamic Nucleus Deep Brain Stimulation for Parkinson's disease.
Viswas Dayal,Timothy Grover,Patricia Limousin,Harith Akram,Davide Cappon,Joseph Candelario,Maricel Salazar,Elina Tripoliti,Ludvic Zrinzo,Jonathan Hyam,Marjan Jahanshahi,Marwan Hariz,Thomas Foltynie +12 more
TL;DR: STN-DBS in PD patients using a PW of 30μs significantly increases the TW compared to standard PW settings, and this effect is consistent across all contacts of an electrode.
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Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson's disease.
Anam Anzak,L. Gaynor,Mazda Beigi,Thomas Foltynie,Patricia Limousin,Ludvic Zrinzo,Peter Brown,Marjan Jahanshahi +7 more
TL;DR: It is suggested that STN gamma activity is relevant for controlled processing, in particular the active selection and repetition of the same number on successive trials in paced random number generation participants.
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Gene therapy: a viable therapeutic strategy for Parkinson’s disease?
TL;DR: This review presents an overview of the four gene therapies in phase I/II clinical trials, outlines some of the challenges they face, and proposes additional alternative strategies that might improve the clinical prospects of gene therapy for PD.
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The Parkinsonian subthalamic network: measures of power, linear, and non-linear synchronization and their relationship to L-DOPA treatment and OFF state motor severity
Tim West,Simon F. Farmer,Luc Berthouze,Luc Berthouze,Ashwani Jha,Martijn Beudel,Thomas Foltynie,Patricia Limousin,Ludvic Zrinzo,Peter Brown,Peter Brown,Vladimir Litvak +11 more
TL;DR: The ability of non-linear measures to predict clinical state did not exceed standard measures such as beta power, but these measures may help identify the connections which play a role in pathological dynamics.
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Changing of the guard: reducing infection when replacing neural pacemakers
Joshua Pepper,Lara Meliak,Harith Akram,Jonathan Hyam,Catherine Milabo,Joseph Candelario,Thomas Foltynie,Patricia Limousin,Carmel Curtis,Marwan Hariz,Marwan Hariz,Ludvic Zrinzo +11 more
TL;DR: It is suggested that a change in clinical practice can significantly lower infection rates in patients undergoing DBS IPG replacement, and simple measures can minimize unnecessary surgery, loss of benefit from chronic stimulation, and costly hardware replacement, further improving the cost efficacy of DBS therapies.