T
Thomas Foltynie
Researcher at UCL Institute of Neurology
Publications - 381
Citations - 26959
Thomas Foltynie is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 80, co-authored 352 publications receiving 21023 citations. Previous affiliations of Thomas Foltynie include University College London & University of Kent.
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Journal ArticleDOI
Tau and α-synuclein in susceptibility to, and dementia in, Parkinson's disease
An Goris,An Goris,Caroline H. Williams-Gray,Graeme R. Clark,Thomas Foltynie,Simon J.G. Lewis,Joanne Brown,Maria Ban,Maria Grazia Spillantini,Alastair Compston,David J. Burn,Patrick F. Chinnery,Roger A. Barker,Stephen Sawcer +13 more
TL;DR: The genetic basis of susceptibility to and cognitive heterogeneity of Parkinson's disease is investigated and it is found that the former is linked to higher levels of cognitive impairment and the latter to decreased mobility.
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Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease: Two Case Reports
Zinovia Kefalopoulou,Marios Politis,Paola Piccini,Niccolo E. Mencacci,Kailash P. Bhatia,Marjan Jahanshahi,Håkan Widner,Stig Rehncrona,Patrik Brundin,Anders Björklund,Olle Lindvall,Patricia Limousin,Niall Quinn,Thomas Foltynie +13 more
TL;DR: The results from these 2 cases indicate that dopaminergic cell transplantation can offer very long-term symptomatic relief in patients with Parkinson disease and provide proof-of-concept support for future clinical trials using fetal or stem cell therapies.
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MRI-guided STN DBS in Parkinson's disease without microelectrode recording: efficacy and safety
Thomas Foltynie,Ludvic Zrinzo,Irene Martinez-Torres,Elina Tripoliti,Erika A. Petersen,Etienne Holl,Iciar Aviles-Olmos,Marjan Jahanshahi,Marwan Hariz,Patricia Limousin +9 more
TL;DR: It is confirmed that image-guided STN DBS without microelectrode recording can lead to substantial improvements in motor disability of well-selected PD patients with accompanying improvements in quality of life and most importantly, with very low morbidity.
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Parkinson's disease, insulin resistance and novel agents of neuroprotection
TL;DR: In this article, convergence evidence identifying that peroxisome proliferator activated receptor gamma coactivator 1-α, a key regulator of enzymes involved in mitochondrial respiration and insulin resistance, is potentially pivotal in the pathogenesis of neurodegeneration in Parkinson's disease.
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The heterogeneity of idiopathic Parkinson's disease.
TL;DR: Evidence suggests that sub-groups based on age of onset, motor presentation, or subsequent motor phenotype may have some use in predicting disease progression, however, further clinico-pathological studies are required to evaluate pathological heterogeneity within these groups.