T
Thomas Foltynie
Researcher at UCL Institute of Neurology
Publications - 381
Citations - 26959
Thomas Foltynie is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 80, co-authored 352 publications receiving 21023 citations. Previous affiliations of Thomas Foltynie include University College London & University of Kent.
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Journal ArticleDOI
Genetic analysis of Mendelian mutations in a large UK population-based Parkinson's disease study.
Manuela Tan,Naveed Malek,Michael A Lawton,Leon Hubbard,Alan M. Pittman,Theresita Joseph,Jason Hehir,Diane M A Swallow,Katherine A Grosset,Sarah L Marrinan,Nin Bajaj,Roger A. Barker,Roger A. Barker,David J. Burn,Catherine Bresner,Thomas Foltynie,John Hardy,Nicholas W. Wood,Yoav Ben-Shlomo,Donald G. Grosset,Nigel Williams,Huw R. Morris +21 more
TL;DR: In a large population-based study, Tan et al. show that pathogenic mutations are present in 1.4% of UK patients with Parkinson’s disease and are more common in those with early-onset or familial disease.
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Pyramidal tract activation due to subthalamic deep brain stimulation in Parkinson's disease.
Philipp Mahlknecht,Harith Akram,Dejan Georgiev,Elina Tripoliti,Joseph Candelario,Andre Zacharia,Ludvic Zrinzo,Jonathan A. Hyam,Marwan Hariz,Thomas Foltynie,John C. Rothwell,Patricia Limousin +11 more
TL;DR: Subthalamic deep brain stimulation is an effective treatment for Parkinson's disease, but can have side effects caused by stimulus spread to structures outside the target volume such as the pyramidal tract.
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Oscillatory Beta Power Correlates With Akinesia‐Rigidity in the Parkinsonian Subthalamic Nucleus
Martijn Beudel,Martijn Beudel,Ashwini Oswal,Ashwini Oswal,Ashwani Jha,Thomas Foltynie,Ludvic Zrinzo,Marwan Hariz,Patricia Limousin,Vladimir Litvak +9 more
TL;DR: The data suggest that PSD correlations may be strongest with AR, and the degree of neural synchronization (as indexed by PSD) rather than any specific frequency over the 8 to 35 Hz band that is most important.
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Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome
Kara A. Johnson,Kara A. Johnson,Gordon Duffley,Gordon Duffley,Daria Nesterovich Anderson,Daria Nesterovich Anderson,Jill L. Ostrem,Marie-Laure Welter,Juan Carlos Baldermann,Jens Kuhn,Daniel Huys,Veerle Visser-Vandewalle,Thomas Foltynie,Ludvic Zrinzo,Marwan Hariz,Marwan Hariz,Albert F.G. Leentjens,Alon Y. Mogilner,Michael H. Pourfar,Leonardo Almeida,Aysegul Gunduz,Kelly D. Foote,Michael S. Okun,Christopher R. Butson +23 more
TL;DR: The results demonstrate that the structural connectivity of the site of stimulation are likely important for mediating symptom improvement, and the networks involved in tic improvement may differ across surgical targets.
Journal ArticleDOI
Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease: a cross-sectional study of iron-related magnetic resonance imaging susceptibility.
Antonio Martin-Bastida,Nicholas P. Lao-Kaim,Clare Loane,Clare Loane,Marios Politis,Marios Politis,Andreas-Antonios Roussakis,Natalie Valle-Guzman,Zinovia Kefalopoulou,Gesine Paul-Visse,Håkan Widner,Yue Xing,Stefan Schwarz,Dorothee P. Auer,Thomas Foltynie,Roger A. Barker,Roger A. Barker,Paola Piccini +17 more
TL;DR: To determine whether iron deposition in deep brain nuclei assessed using high‐pass filtered phase imaging plays a role in motor disease severity in Parkinson's disease, data are analyzed through positron emission tomography and electrophysiology.