T
Thomas Foltynie
Researcher at UCL Institute of Neurology
Publications - 381
Citations - 26959
Thomas Foltynie is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 80, co-authored 352 publications receiving 21023 citations. Previous affiliations of Thomas Foltynie include University College London & University of Kent.
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Journal ArticleDOI
Midline Frontal Cortex Low-Frequency Activity Drives Subthalamic Nucleus Oscillations during Conflict
Baltazar Zavala,Huiling Tan,Simon Little,Keyoumars Ashkan,Marwan Hariz,Thomas Foltynie,Ludvic Zrinzo,Kareem A. Zaghloul,Peter Brown +8 more
TL;DR: The cortico-subcortical circuit enabling successful choices to be made under conditions of conflict is established and support for the hypothesis that the brain uses frequency-specific channels of communication to convey behaviorally relevant information is provided.
Journal ArticleDOI
Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients with Parkinson Disease: A Secondary Analysis of the Exenatide-PD Trial
Dilan Athauda,Seema Gulyani,Hanuma Kumar Karnati,Yazhou Li,David Tweedie,Maja Mustapić,Sahil Chawla,Kashfia Chowdhury,Simon S. Skene,Simon S. Skene,Nigel H. Greig,Dimitrios Kapogiannis,Thomas Foltynie +12 more
TL;DR: Exenatide, a glucagon-like peptide 1 agonist used in type 2 diabetes, was recently found to have beneficial effects on motor function in a randomized, placebo-controlled trial in Parkinson disease.
Journal ArticleDOI
BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease.
Thomas Foltynie,Thomas Foltynie,Binith Cheeran,Caroline H. Williams-Gray,Mark J. Edwards,Susanne A. Schneider,Daniel R. Weinberger,John C. Rothwell,Roger A. Barker,Kailash P. Bhatia +9 more
TL;DR: In this article, the influence of a common functional polymorphism of the BDNF gene on the risk of developing dyskinesias in a large cohort of patients with Parkinson's disease, who were independently and variably treated with levodopa and/or other dopaminergic treatments, was investigated.
Journal ArticleDOI
The nucleus basalis of Meynert: A new target for deep brain stimulation in dementia?
James Gratwicke,Joshua Kahan,Ludvic Zrinzo,Marwan Hariz,Patricia Limousin,Thomas Foltynie,Marjan Jahanshahi +6 more
TL;DR: The anatomy, intrinsic organization and connectivity of the cholinergic nucleus basalis of Meynert, a basal forebrain structure implicated in cognitive functions including memory, attention, arousal and perception, are described and postulate that deep brain stimulation to this nucleus may be able to improve specific cognitive functions.
Journal ArticleDOI
Prediction of cognition in Parkinson's disease with a clinical-genetic score : a longitudinal analysis of nine cohorts
Ganqiang Liu,Joseph J. Locascio,Joseph J. Locascio,Jean-Christophe Corvol,Brendon P. Boot,Brendon P. Boot,Zhixiang Liao,Kara Page,Kara Page,Daly Franco,Daly Franco,Kyle Burke,Kyle Burke,Iris E. Jansen,Iris E. Jansen,Ana Trisini-Lipsanopoulos,Ana Trisini-Lipsanopoulos,Sophie Winder-Rhodes,Caroline M. Tanner,Anthony E. Lang,Shirley Eberly,Alexis Elbaz,Alexis Brice,Graziella Mangone,Bernard Ravina,Ira Shoulson,Florence Cormier-Dequaire,Peter Heutink,Peter Heutink,Jacobus J. van Hilten,Roger A. Barker,Caroline H. Williams-Gray,Johan Marinus,Clemens R Scherzer,Bradley T. Hyman,Adrian J. Ivinson,Lewis Sudarsky,Michael T. Hayes,Chizoba C. Umeh,Reisa A. Sperling,John H. Growdon,Michael A. Schwarzschild,Albert Y. Hung,Alice W. Flaherty,Deborah Blacker,Anne-Marie Wills,U. Shivraj Sohur,Nicte I. Mejia,Anand Viswanathan,Stephen N. Gomperts,Vikram Khurana,Mark W. Albers,Maria Alora-Palli,Scott M. McGinnis,Nutan Sharma,Bradford C. Dickerson,Matthew P. Frosch,Teresa Gomez-Isla,Steven M. Greenberg,James F. Gusella,Trey Hedden,E. Tessa Hedley-Whyte,Aaron M. Koenig,Marta Marquis-Sayagues,Gad A. Marshall,Olivia I. Okereke,Anat Stemmer-Rachaminov,Jessica Kloppenburg,Michael G. Schlossmacher,Dennis J. Selkoe,Thomas Yi,Haining Li,Gabriel Stalberg,Roger A. Barker,Thomas Foltynie,CH Williams-Gray,Trevor W. Robbins,Carol Brayne,Sarah L Mason,David P. Breen,Gemma Cummins,J.M. Evans,Alain Mallet,Marie Vidailhet,Anne-Marie Bonnet,Cecilia Bonnet,David Grabli,Andreas Hartmann,Stephan Klebe,Lucette Lacomblez,Frédéric Bourdain,Jean-Philippe Brandel,Pascal Derkinderen,Franck Durif,Valérie Mesnage,Fernando Pico,Olivier Rascol,Christine Brefel-Courbon,Fabienne Ory-Magne,Sylvie Forlani,Suzanne Lesage,Khadija Tahiri,Roger L. Albin,Roy N. Alcalay,Alberto Ascherio,Dubois Bowman,Alice Chen-Plotkin,Ted M. Dawson,Richard B. Dewey,Dwight C. German,Rachel Saunders-Pullman,Clemens R. Scherzer,David E. Vaillancourt,Vladislav A. Petyuk,Andrew B. West,Jing Zhang +115 more
TL;DR: A prediction algorithm for global cognitive impairment (defined as Mini Mental State Examination ≤25) using data from nine cohorts of patients with Parkinson's disease from North America and Europe assessed between 1986 and 2016 is built.