T
Thomas Foltynie
Researcher at UCL Institute of Neurology
Publications - 381
Citations - 26959
Thomas Foltynie is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Deep brain stimulation & Parkinson's disease. The author has an hindex of 80, co-authored 352 publications receiving 21023 citations. Previous affiliations of Thomas Foltynie include University College London & University of Kent.
Papers
More filters
Journal ArticleDOI
Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson's disease applied retrospectively in a large cohort study of recent onset cases
Naveed Malek,Michael A Lawton,Katherine A Grosset,Nin Bajaj,Roger A. Barker,Yoav Ben-Shlomo,David J. Burn,Thomas Foltynie,John Hardy,Huw R. Morris,Nigel Williams,Nicholas W. Wood,Donald G. Grosset +12 more
TL;DR: Over 90% of cases clinically diagnosed as early PD fulfilled the MDS criteria for PD, and those not fulfilling criteria may have an atypical parkinsonian disorder or secondary parkinsonism that is not correctly identified by the UK Brain Bank criteria, but possibly by the new criteria.
Journal ArticleDOI
Ropinirole, a dopamine agonist with high D3 affinity, reduces proactive inhibition: A double-blind, placebo-controlled study in healthy adults.
TL;DR: A double-blind, placebo-controlled study of 1 mg ropinirole (a dopamine agonist) on response inhibition in healthy volunteers found that whilst reactive inhibition was unchanged, proactive inhibition was impaired when participants were on ro pinirole relative to when on placebo.
Journal ArticleDOI
How Does Deep Brain Stimulation Change the Course of Parkinson's Disease?
TL;DR: There are signals from controlled long‐term observational studies suggesting that subthalamic DBS may delay some of the late‐stage disability milestones including psychosis, falls, and institutionalization, and also slightly prolongs survival compared with matched medically managed patients.
Journal ArticleDOI
Analysis of ATP13A2 in large neurodegeneration with brain iron accumulation (NBIA) and dystonia-parkinsonism cohorts
Michael C. Kruer,Reema Paudel,Wendy Wagoner,Lynn Sanford,Eleanna Kara,Allison Gregory,Thomas Foltynie,Andrew J. Lees,Kailash P. Bhatia,John Hardy,Susan J. Hayflick,Henry Houlden +11 more
TL;DR: The results indicate that ATP13A2 mutations are a rare cause of both NBIA and dystonia-parkinsonism.
Journal ArticleDOI
Entraining stepping movements of Parkinson’s patients to alternating subthalamic nucleus deep brain stimulation
Petra Fischer,Shenghong He,Alexis de Roquemaurel,Harith Akram,Thomas Foltynie,Patricia Limousin,Ludvic Zrinzo,Jonathan Hyam,Hayriye Cagnan,Peter Brown,Huiling Tan +10 more
TL;DR: The study suggests that the STN is causally involved in dynamic control of step timing and motivates further exploration of this biomimetic stimulation pattern as a potential basis for the development of DBS strategies to ameliorate gait impairments.