Tijana Mirjanic

TL;DR: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity, and speech illusions may represent a trait-dependent risk marker.

TL;DR: A review of the recent developments and how integrated, large-scale investigations may overcome contemporary challenges in G × E research can be found in this paper, drawing on the example of a large, international, multi-center study into the identification and translational application of gene-environment interactions in schizophrenia.

TL;DR: The results suggest that the etiopathogenesis of schizophrenia involves genetic underpinnings that act by making individuals more sensitive to the effects of some environmental exposures, including cannabis use and exposure to early‐life adversities.

TL;DR: It is shown how predictive modeling approaches can be used to construct an exposome score (ES) for schizophrenia by applying logistic regression, Gaussian Naive Bayes, and the least absolute shrinkage and selection operator to the training and validation datasets.

TL;DR: The interplay between exposome load and schizophrenia genetic liability contributing to psychosis across the spectrum of expression provide further empirical support to the notion of aetiological continuity underlying an extended psychosis phenotype.