M
Mara Parellada
Researcher at Hospital General Universitario Gregorio Marañón
Publications - 4
Citations - 457
Mara Parellada is an academic researcher from Hospital General Universitario Gregorio Marañón. The author has contributed to research in topics: Autism & Exposome. The author has an hindex of 3, co-authored 4 publications receiving 320 citations. Previous affiliations of Mara Parellada include Oregon Health & Science University & University of Belgrade.
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Journal ArticleDOI
Cortical and Subcortical Brain Morphometry Differences Between Patients With Autism Spectrum Disorder and Healthy Individuals Across the Lifespan: Results From the ENIGMA ASD Working Group
Daan van Rooij,Evdokia Anagnostou,Celso Arango,Guillaume Auzias,Marlene Behrmann,Geraldo F. Busatto,Sara Calderoni,Eileen Daly,Christine Deruelle,Adriana Di Martino,Ilan Dinstein,Fabio Luis Souza Duran,Sarah Durston,Christine Ecker,Damien A. Fair,Jennifer Fedor,Jackie Fitzgerald,Christine M. Freitag,Louise Gallagher,Ilaria Gori,Shlomi Haar,Liesbeth Hoekstra,Neda Jahanshad,Maria Jalbrzikowski,Joost Janssen,Jason Lerch,Beatriz Luna,Mauricio Moller Martinho,Jane McGrath,Filippo Muratori,Clodagh M. Murphy,Declan Murphy,Kirsten O'Hearn,Bob Oranje,Mara Parellada,Alessandra Retico,Pedro G.P. Rosa,Katya Rubia,Devon Shook,Margot J. Taylor,Paul M. Thompson,Michela Tosetti,Gregory L. Wallace,Fengfeng Zhou,Jan K. Buitelaar +44 more
TL;DR: Findings suggest an interplay in the abnormal development of the striatal, frontal, and temporal regions in ASD across the lifespan, using a well-established, validated, publicly available analysis pipeline.
Posted ContentDOI
Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism
Satterstrom Fk,Satterstrom Fk,Jack A. Kosmicki,Jiebiao Wang,Michael S. Breen,De Rubeis S,Joon Yong An,Minshi Peng,Ryan L. Collins,Jakob Grove,Jakob Grove,Lambertus Klei,Cathy A. Stevens,Jennifer Reichert,Maureen Mulhern,Mykyta Artomov,Sherif Gerges,Brooke Sheppard,Xinyi Xu,Aparna Bhaduri,Utku Norman,Harrison Brand,Grace Schwartz,Rachel Nguyen,Elizabeth E. Guerrero,Caroline Dias,Branko Aleksic,Anney Rjl,Mafalda Barbosa,Somer L. Bishop,Alfredo Brusco,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Angel Carracedo,Chan Mcy,Andreas G. Chiocchetti,Brian H.Y. Chung,Hilary Coon,Michael L. Cuccaro,Aurora Currò,Dalla Bernardina B,Ryan N. Doan,Enrico Domenici,Shan Dong,Chiara Fallerini,Montse Fernández-Prieto,Giovanni Battista Ferrero,Christine M. Freitag,Menachem Fromer,Jay Gargus,Daniel H. Geschwind,Elisa Giorgio,Javier González-Peñas,Stephen J. Guter,Danielle Halpern,Hassen-Kiss E,Xin He,Gail E. Herman,Irva Hertz-Picciotto,David M. Hougaard,David M. Hougaard,Christina M. Hultman,Iuliana Ionita-Laza,Suma Jacob,Jesslyn Jamison,Astanand Jugessur,Miia Kaartinen,Gun Peggy Knudsen,Alexander Kolevzon,Itaru Kushima,So Lun Lee,Terho Lehtimäki,Elaine T. Lim,Carla Lintas,Lipkin Wi,Diego Lopergolo,Fátima Lopes,Yunin Ludena,Patrícia Maciel,Per Magnus,Behrang Mahjani,Nell Maltman,Dara S. Manoach,Gal Meiri,Idan Menashe,Judith Miller,Nancy J. Minshew,Montenegro M. de Souza E,Danielle de Paula Moreira,Eric M. Morrow,Ole Mors,Ole Mors,Preben Bo Mortensen,Matthew W. Mosconi,Pierandrea Muglia,Benjamin M. Neale,Benjamin M. Neale,Merete Nordentoft,Merete Nordentoft,Norio Ozaki,Aarno Palotie,Mara Parellada,Maria Rita Passos-Bueno,Margaret A. Pericak-Vance,Antonio M. Persico,Isaac N. Pessah,Kaija Puura,Abraham Reichenberg,Alessandra Renieri,Evelise Riberi,Elise B. Robinson,Elise B. Robinson,Kaitlin E. Samocha,Sven Sandin,Sven Sandin,Susan L. Santangelo,Susan L. Santangelo,Gerry Schellenberg,Stephen W. Scherer,Stephen W. Scherer,Sabine Schlitt,Rebecca J. Schmidt,Lauren M. Schmitt,Silva Imw,Tarjinder Singh,Paige M. Siper,Megan Smith,Gabriela Soares,Camilla Stoltenberg,Pål Surén,Ezra Susser,Ezra Susser,John A. Sweeney,Peter Szatmari,Lara Tang,Flora Tassone,Karoline Teufel,Elisabetta Trabetti,Trelles Mdp,Christopher A. Walsh,Lauren A. Weiss,Thomas Werge,Thomas Werge,Thomas Werge,Donna M. Werling,Emilie M. Wigdor,Emilie M. Wigdor,Emma Wilkinson,Jeremy Willsey,Timothy W. Yu,Yu Mhc,Ryan K. C. Yuen,Elaine Cristina Zachi,Catalina Betancur,Edwin H. Cook,Louise Gallagher,Michael Gill,Lehner T,Senthil G,James S. Sutcliffe,Audrey Thurm,Michael E. Zwick,Anders D. Børglum,Matthew W. State,Cicek Ae,Michael E. Talkowski,David J. Cutler,Bernie Devlin,Stephen Sanders,Kathryn Roeder,Joseph D. Buxbaum,Mark J. Daly +171 more
TL;DR: Using an enhanced Bayesian framework to integrate de novo and case-control rare variation, 102 risk genes are identified at a false discovery rate of ≤ 0.1, consistent with multiple paths to an excitatory/inhibitory imbalance underlying ASD.
Journal ArticleDOI
Estimating exposome score for schizophrenia using predictive modeling approach in two independent samples: the results from the EUGEI study
Genetic Risk,Lotta-Katrin Pries,Agustin Lage-Castellanos,Philippe Delespaul,Gunter Kenis,Jurjen J. Luykx,Bochao D. Lin,Alexander Richards,Berna Binnur Akdede,Tolga Binbay,Vesile Altınyazar,Berna Yalınçetin,Güvem Gümüş-Akay,Burçin Cihan,Haldun Soygür,Halis Ulaş,Eylem Sahin Cankurtaran,Semra Ulusoy Kaymak,Marina Mihaljevic,Sanja Andric Petrovic,Tijana Mirjanic,Miguel Bernardo,Bibiana Cabrera,Julio Bobes,Pilar A. Saiz,Maria Paz Garcia-Portilla,Julio Sanjuán,Eduardo J. Aguilar,José Luis Santos,Estela Jiménez-López,Manuel Arrojo,Angel Carracedo,Gonzalo López,Javier González-Peñas,Mara Parellada,Nadja P. Maric,Cem Atbaşoğlu,Alp Üçok,Köksal Alptekin,Meram Can Saka,Celso Arango,Michael Conlon O'Donovan,Bart P. F. Rutten,Jim van Os,Jim van Os,Sinan Guloksuz +45 more
TL;DR: It is shown how predictive modeling approaches can be used to construct an exposome score (ES) for schizophrenia by applying logistic regression, Gaussian Naive Bayes, and the least absolute shrinkage and selection operator to the training and validation datasets.
Posted ContentDOI
Analyses of rare and common alleles in parent-proband trios implicate rare missense variants in SLC6A1 in schizophrenia and confirm the involvement of loss of function intolerant and neurodevelopmental disorder genes
E. Rees,Jun Han,James Edwards Morgan,Noa Carrera,Escott-Price,Andrew Pocklington,Madeleine Duffield,Lynsey S. Hall,Sophie E. Legge,Antonio F. Pardiñas,Alexander Richards,Julian Roth,Lezheiko T,Kondratyev N,Golimbet,Mara Parellada,Javier González-Peñas,Celso Arango,Micha Gawlik,G. Kirov,Walters Jtr,Peter Holmans,M O'Donovan,M. J. Owen +23 more
TL;DR: DNV analysis in whole exome-sequencing data obtained from a new sample of 613 schizophrenia trios was performed, and combined this with published data for a total of 3,444 trios, providing robust support for the hypothesis that this set of DNVs is enriched for those related to schizophrenia.