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Jurjen J. Luykx

Researcher at Utrecht University

Publications -  193
Citations -  5815

Jurjen J. Luykx is an academic researcher from Utrecht University. The author has contributed to research in topics: Medicine & Schizophrenia. The author has an hindex of 23, co-authored 145 publications receiving 2889 citations. Previous affiliations of Jurjen J. Luykx include University of California, Berkeley & University of California, Los Angeles.

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Journal ArticleDOI

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
- 12 Dec 2019 - 
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
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Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy, +432 more
- 08 Apr 2022 - 
TL;DR: In this article , a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals was conducted, and the authors reported common variant associations at 287 distinct genomic loci.
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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Hunna J. Watson, +258 more
- 01 Aug 2019 - 
TL;DR: The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index.
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The genetic architecture of the human cerebral cortex

Katrina L. Grasby, +359 more
- 20 Mar 2020 - 
TL;DR: Results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness and find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.
Posted ContentDOI

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

Phil Lee, +58 more
- 26 Jan 2019 - 
TL;DR: A meta-analysis of genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome revealed a meaningful structure within the eight disorders identifying three groups of inter-related disorders.