T
Timothy L. Ratliff
Researcher at Purdue University
Publications - 312
Citations - 20541
Timothy L. Ratliff is an academic researcher from Purdue University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 69, co-authored 306 publications receiving 19092 citations. Previous affiliations of Timothy L. Ratliff include University of Iowa Hospitals and Clinics & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Measurement of prostate-specific antigen in serum as a screening test for prostate cancer.
William J. Catalona,Deborah S. Smith,Timothy L. Ratliff,Kathy M. Dodds,Douglas E. Coplen,Jerry J.J. Yuan,John A. Petros,Gerald L. Andriole +7 more
TL;DR: The combination of measurement of the serum PSA concentration and rectal examination, with ultrasonography performed in patients with abnormal findings, provides a better method of detecting prostate cancer thanrectal examination alone.
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Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men.
William J. Catalona,Jerome P. Richie,Frederick R. Ahmann,M'Liss A. Hudson,Peter T. Scardino,Robert C. Flanigan,Jean B. deKernion,Timothy L. Ratliff,Louis R. Kavoussi,Bruce L. Dalkin,W. Bedford Waters,Michael T. Macfarlane,Paula C. Southwick +12 more
TL;DR: In this paper, a prospective clinical trial at 6 university centers of 6,630 male volunteers 50 years old or older who underwent PSA determination (Hybritech Tandom-E or Tandem-R assays) and digital rectal examination was conducted.
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Detection of organ-confined prostate cancer is increased through prostate-specific antigen-based screening.
TL;DR: Screening based on PSA identifies some men with prostate cancer who have a significantly increased proportion of organ-confined tumors compared with those detected through evaluation for an abnormal digital rectal examination alone.
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Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening.
William J. Catalona,Deborah S. Smith,Robert L. Wolfert,Tang J. Wang,Harry G. Rittenhouse,Timothy L. Ratliff,Robert B. Nadler +6 more
TL;DR: Measurement of percentage of free PSA in serum improves specificity of prostate cancer screening in selected men with elevated total serum PSA levels and can reduce unnecessary prostate biopsies with minimal effects on the cancer detection rate; however, further studies are needed to define optimal cutoffs.
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Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness
Shuhua Yue,Junjie Li,Seung Young Lee,Hyeon Jeong Lee,Tian Shao,Bing Song,Liang Cheng,Timothy A. Masterson,Xiaoqi Liu,Timothy L. Ratliff,Ji-Xin Cheng +10 more
TL;DR: Biochemical study showed that cholesteryl ester accumulation was a consequence of loss of tumor suppressor PTEN and subsequent activation of PI3K/AKT pathway in prostate cancer cells, and open opportunities for diagnosing and treating prostate cancer by targeting the altered cholesterol metabolism.