T
Tom Callens
Researcher at University of Alabama at Birmingham
Publications - 46
Citations - 2446
Tom Callens is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Population & Gene. The author has an hindex of 25, co-authored 45 publications receiving 2123 citations. Previous affiliations of Tom Callens include Ghent University & Ghent University Hospital.
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Journal ArticleDOI
Human myosin V gene produces different transcripts in a cell type-specific manner.
TL;DR: This is the first report showing the presence of exon F as well as alternative splicing in the human myosin V tail domain, which is the full-length transcript most abundant in melanocytes and leukocytes and both cell types are involved in Griscelli syndrome.
Journal ArticleDOI
Bax expression is a candidate prognostic and predictive marker of colorectal cancer
Venkat R. Katkoori,Catalina Suarez-Cuervo,Chandrakumar Shanmugam,Nirag Jhala,Tom Callens,Ludwine Messiaen,James Posey,Harvey L. Bumpers,Sreelatha Meleth,William E. Grizzle,Upender Manne +10 more
TL;DR: These findings are the first to demonstrate that high Bax expression is a good prognosticator for patients who underwent surgery alone, and that patient with low Bax/Bcl-2 expression ratio benefit from 5-FU-based adjuvant therapies.
Journal ArticleDOI
Genetic and clinical mosaicism in a patient with neurofibromatosis type 1
Ina Vandenbroucke,Remco van Doorn,Tom Callens,Tom Callens,Jan M. Cobben,Theo M. Starink,Ludwine Messiaen,Ludwine Messiaen +7 more
TL;DR: The findings in this patient demonstrate that although the entire body is affected, mosaicism can still be suspected at clinical examination and proven by DNA analysis and skin biopsies, and long-range RT-PCR is a feasible method for demonstrating large intragenic deletions in NF1.
Journal ArticleDOI
Exon 10b of the NF1 gene represents a mutational hotspot and harbors a recurrent missense mutation Y489C associated with aberrant splicing.
Ludwine Messiaen,Tom Callens,Kyle J. Roux,Geert Mortier,Anne De Paepe,Marc Abramowicz,Margaret A. Pericak-Vance,Jeffery M. Vance,Margaret R. Wallace +8 more
TL;DR: As exon 10b show the highest mutation rate yet found in any of the 60 NF1 exon, it should be implemented with priority in mutation analysis.
Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype-phenotype correlation
Magdalena Koczkowska,Tom Callens,Alicia Gomes,Angela Sharp,Yunjia Chen,Alesha D. Hicks,Arthur S. Aylsworth,Amedeo A. Azizi,Donald Basel,Gary Bellus,Lynne M. Bird,Maria Blazo,Leah W. Burke,Ashley Cannon,Felicity Collins,Colette DeFilippo,Ellen Denayer,Maria Cristina Digilio,Shelley K. Dills,Laura Dosa,Robert S. Greenwood,Cristin Griffis,Punita Gupta,Rachel K. Hachen,Concepción Hernández-Chico,Sandra Janssens,Kristi J. Jones,Justin T. Jordan,Peter Kannu,Bruce R. Korf,Andrea M. Lewis,Robert Listernick,Fortunato Lonardo,Maurice J. Mahoney,Mayra Martinez Ojeda,Marie T. McDonald,Carey McDougall,Nancy J. Mendelsohn,David T. Miller,Mari Mori,Rianne Oostenbrink,Sébastien Perreault,Mary Ella M Pierpont,Carmelo Piscopo,Dinel A. Pond,Linda M. Randolph,Katherine A. Rauen,Surya P. Rednam,S. Lane Rutledge,Veronica Saletti,G. Bradley Schaefer,Elizabeth K. Schorry,Daryl A. Scott,Andrea Shugar,Elizabeth Siqveland,Lois J. Starr,Ashraf Syed,Pamela Trapane,Nicole J. Ullrich,Emily Wakefield,Laurence E. Walsh,Michael F. Wangler,Elaine H. Zackai,Kathleen Claes,Katharina Wimmer,Rick van Minkelen,Alessandro De Luca,Yolanda Martin,Eric Legius,Ludwine Messiaen +69 more
TL;DR: A correction has been published to this article as discussed by the authors, and the PDF and HTML have been updated accordingly to reflect the correction. But the content of this article is not changed in this article.