T
Ting Bai
Researcher at Central South University
Publications - 12
Citations - 537
Ting Bai is an academic researcher from Central South University. The author has contributed to research in topics: Autism & Missense mutation. The author has an hindex of 8, co-authored 11 publications receiving 373 citations.
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Journal ArticleDOI
De novo genic mutations among a Chinese autism spectrum disorder cohort
Tianyun Wang,Hui Guo,Bo Xiong,Holly A.F. Stessman,Huidan Wu,Bradley P. Coe,Tychele N. Turner,Yanling Liu,Wenjing Zhao,Kendra Hoekzema,Laura Vives,Lu Xia,Meina Tang,Jianjun Ou,Biyuan Chen,Yidong Shen,Guanglei Xun,Min Long,Janice Lin,Zev N. Kronenberg,Yu Peng,Ting Bai,Honghui Li,Xiaoyan Ke,Zhengmao Hu,Jingping Zhao,Xiaobing Zou,Kun Xia,Evan E. Eichler +28 more
TL;DR: Phenotypic follow-up confirms potential subtypes and highlights how large global cohorts might be leveraged to prove the pathogenic significance of individually rare mutations.
Journal ArticleDOI
Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model
Hui Guo,Hui Guo,Tianyun Wang,Tianyun Wang,Huidan Wu,Min Long,Bradley P. Coe,Honghui Li,Guanglei Xun,Jianjun Ou,Biyuan Chen,Guiqin Duan,Ting Bai,Ningxia Zhao,Yidong Shen,Yun Li,Yazhe Wang,Yu Zhang,Carl Baker,Yanling Liu,Nan Pang,Lian Huang,Lin Han,Xiangbin Jia,Cenying Liu,Hailun Ni,Xinyi Yang,Lu Xia,Jingjing Chen,Lu Shen,Ying Li,Rongjuan Zhao,Wenjing Zhao,J Peng,Qian Pan,Zhigao Long,Wei Su,Jieqiong Tan,Xiaogang Du,Xiaoyan Ke,Meiling Yao,Zhengmao Hu,Xiaobing Zou,Jingping Zhao,Raphael Bernier,Evan E. Eichler,Kun Xia +46 more
TL;DR: The fact that parental carriers show milder phenotypes and patients with multiple hits in different autism risk genes are more severe supports a multifactorial model of risk.
Journal ArticleDOI
Genome-wide copy number variation analysis in a Chinese autism spectrum disorder cohort
Hui Guo,Yu Peng,Zhengmao Hu,Ying Li,Guanglei Xun,Jianjun Ou,Liangdan Sun,Zhimin Xiong,Yanling Liu,Tianyun Wang,Jingjing Chen,Lu Xia,Ting Bai,Yidong Shen,Qi Tian,Yiqiao Hu,Lu Shen,Rongjuan Zhao,Xuejun Zhang,Fengyu Zhang,Fengyu Zhang,Jingping Zhao,Xiaobing Zou,Kun Xia,Kun Xia +24 more
TL;DR: This study identifies ASD-related CNVs in a Chinese population and implicate novel ASD risk genes and related pathway for further study, and implicated Contactins-NYAPs-WAVE1 pathway in ASD pathogenesis.
Journal ArticleDOI
Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission
Hui Guo,Hui Guo,Ying Li,Lu Shen,Tianyun Wang,Tianyun Wang,Xiangbin Jia,Lijuan Liu,Tao Xu,Mengzhu Ou,Kendra Hoekzema,Huidan Wu,Madelyn A. Gillentine,Cenying Liu,Hailun Ni,Pengwei Peng,Rongjuan Zhao,Yu Zhang,Chanika Phornphutkul,Alexander P.A. Stegmann,Carlos E. Prada,Robert J. Hopkin,Joseph T. Shieh,Kirsty McWalter,Kristin G. Monaghan,Peter M. van Hasselt,Koen L.I. van Gassen,Ting Bai,Min Long,Lin Han,Yingting Quan,Meilin Chen,Yaowen Zhang,Kuokuo Li,Qiumeng Zhang,Jieqiong Tan,Tengfei Zhu,Yaning Liu,Nan Pang,J Peng,Daryl A. Scott,Seema R. Lalani,Mahshid Azamian,Grazia M.S. Mancini,Darius J. Adams,Malin Kvarnung,Malin Kvarnung,Anna Lindstrand,Anna Lindstrand,Ann Nordgren,Ann Nordgren,Jonathan Pevsner,Jonathan Pevsner,Ikeoluwa A. Osei-Owusu,Ikeoluwa A. Osei-Owusu,Corrado Romano,Giuseppe Calabrese,Ornella Galesi,Jozef Gecz,E. Haan,Judith D. Ranells,Melissa Racobaldo,Magnus Nordenskjöld,Magnus Nordenskjöld,Suneeta Madan-Khetarpal,Jessica Sebastian,Susie Ball,Xiaobing Zou,Jingping Zhao,Zhengmao Hu,Fan Xia,Fan Xia,Pengfei Liu,Pengfei Liu,Jill A. Rosenfeld,Bert B.A. de Vries,Raphael Bernier,Zhi-Qing David Xu,Honghui Li,Wei Xie,Robert B. Hufnagel,Evan E. Eichler,Kun Xia +82 more
TL;DR: A new autism-related syndrome is defined and the functional role of CSDE1 in synapse development and synaptic transmission is highlighted, which is linked to overgrowth of neurites and abnormal dendritic spine morphology/synapse formation and impaired synaptic transmission.
Journal ArticleDOI
Phenotype-to-genotype approach reveals head-circumference-associated genes in an autism spectrum disorder cohort.
Huidan Wu,Honghui Li,Ting Bai,Lin Han,Jianjun Ou,Guanglei Xun,Yu Zhang,Yazhe Wang,Guiqin Duan,Ningxia Zhao,Biyuan Chen,Xiaogang Du,Meiling Yao,Xiaobing Zou,Jingping Zhao,Zhengmao Hu,Evan E. Eichler,Hui Guo,Hui Guo,Kun Xia +19 more
TL;DR: The results suggest a phenotype‐to‐genotype strategy would accelerate the elucidation of genotype‐phenotype relationships for ASD by using phenotype‐restricted cohorts.