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Ulrike Müller
Researcher at Heidelberg University
Publications - 194
Citations - 17349
Ulrike Müller is an academic researcher from Heidelberg University. The author has contributed to research in topics: Amyloid precursor protein & Presenilin. The author has an hindex of 61, co-authored 183 publications receiving 15888 citations. Previous affiliations of Ulrike Müller include Leipzig University & University of Zurich.
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Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
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Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
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GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Robert J. Harvey,Ulrike B. Depner,Heinz Wässle,Seifollah Ahmadi,Cornelia Heindl,Heiko Reinold,Trevor G. Smart,Kirsten Harvey,Burkhard Schütz,Osama M. Abo-Salem,Andreas Zimmer,Pierrick Poisbeau,Hans Welzl,David P. Wolfer,Heinrich Betz,Hanns Ulrich Zeilhofer,Ulrike Müller +16 more
TL;DR: It is demonstrated that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization and may provide a previously unrecognized molecular target in pain therapy.
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Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members
Sabine Heber,Jochen Herms,Vladan Gajic,Johannes A. Hainfellner,Adriano Aguzzi,Thomas Rülicke,Hans A. Kretzschmar,Cornelia von Koch,Sangram S. Sisodia,Phillippe Tremml,Hans-Peter Lipp,David P. Wolfer,Ulrike Müller,Ulrike Müller +13 more
TL;DR: The phenotypes of mice lacking individual or all possible combinations of APP family members are examined and genetic evidence for at least some distinct physiological roles of APP and APLP2 is provided by demonstrating that combinations of single knock-outs with the APLP1 mutation resulted in double mutants of clearly different phenotypes.
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Loss of Postsynaptic GABAA Receptor Clustering in Gephyrin-Deficient Mice
Matthias Kneussel,Johann Helmut Brandstätter,Bodo Laube,Sabine Stahl,Ulrike Müller,Heinrich Betz +5 more
TL;DR: Gephyrin is required for the synaptic localization of GlyRs and GABAA receptors containing the γ2 and/or α2 subunits but not for the targeting of these receptors to the neuronal plasma membrane, which may be important for efficient membrane insertion and/ or metabolic stabilization of inhibitory receptors at developing postsynaptic sites.