Ulrike Müller

TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.

TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.

TL;DR: It is demonstrated that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization and may provide a previously unrecognized molecular target in pain therapy.

TL;DR: The phenotypes of mice lacking individual or all possible combinations of APP family members are examined and genetic evidence for at least some distinct physiological roles of APP and APLP2 is provided by demonstrating that combinations of single knock-outs with the APLP1 mutation resulted in double mutants of clearly different phenotypes.

TL;DR: Gephyrin is required for the synaptic localization of GlyRs and GABAA receptors containing the γ2 and/or α2 subunits but not for the targeting of these receptors to the neuronal plasma membrane, which may be important for efficient membrane insertion and/ or metabolic stabilization of inhibitory receptors at developing postsynaptic sites.