V
Vadim Cherezov
Researcher at University of Southern California
Publications - 196
Citations - 32307
Vadim Cherezov is an academic researcher from University of Southern California. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 72, co-authored 180 publications receiving 28950 citations. Previous affiliations of Vadim Cherezov include Indiana University – Purdue University Indianapolis & Moscow Institute of Physics and Technology.
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Journal ArticleDOI
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
Uwe Weierstall,Daniel James,Chong Wang,Thomas A. White,Dingjie Wang,Wei Liu,John C. H. Spence,R. Bruce Doak,Garrett Nelson,Petra Fromme,Raimund Fromme,Ingo Grotjohann,Christopher Kupitz,Nadia A. Zatsepin,Haiguang Liu,Shibom Basu,Daniel Wacker,Gye Won Han,Vsevolod Katritch,Sébastien Boutet,Marc Messerschmidt,Garth J. Williams,Jason E. Koglin,M. Marvin Seibert,M. Marvin Seibert,Markus Klinker,Cornelius Gati,Robert L. Shoeman,Anton Barty,Henry N. Chapman,Richard A. Kirian,Kenneth R. Beyerlein,Raymond C. Stevens,Dianfan Li,Syed T. A. Shah,Nicole Howe,Martin Caffrey,Vadim Cherezov +37 more
TL;DR: This work presents a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond crystallography.
Journal ArticleDOI
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Huixian Wu,Chong Wang,Karen J. Gregory,Karen J. Gregory,Gye Won Han,Hyekyung P. Cho,Yan Xia,Colleen M. Niswender,Vsevolod Katritch,Jens Meiler,Vadim Cherezov,P. Jeffrey Conn,Raymond C. Stevens +12 more
TL;DR: A combination of crystallography, structure-activity relationships, mutagenesis, and full-length dimer modeling provides insights about the allosteric modulation and activation mechanism of class C GPCRs.
Journal ArticleDOI
Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang,Yi Jiang,Yi Jiang,Jinming Ma,Jinming Ma,Huixian Wu,Daniel Wacker,Vsevolod Katritch,Gye Won Han,Wei Liu,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Xiang Gao,X. Edward Zhou,Karsten Melcher,Chenghai Zhang,Fang Bai,Huaiyu Yang,Linlin Yang,Hualiang Jiang,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens,H. Eric Xu +24 more
TL;DR: Crystal structures of the human 5-HT1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine are reported and provide a comprehensive structural basis for understanding receptor-ligand interactions and designing subtype-selective serotonergic drugs.
Journal ArticleDOI
Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang,Huixian Wu,Vsevolod Katritch,Gye Won Han,Xi Ping Huang,Wei Liu,Fai Yiu Siu,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens +9 more
TL;DR: Although the SMO receptor shares the seven-transmembrane helical fold, most of the conserved motifs for class A GPCRs are absent, and the structure reveals an unusually complex arrangement of long extracellular loops stabilized by four disulphide bonds.
Journal ArticleDOI
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Aaron Thompson,Wei-Wei Liu,Eugene Chun,Vsevolod Katritch,Huixian Wu,Eyal Vardy,Xi Ping Huang,Claudio Trapella,Remo Guerrini,Girolamo Calo,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens +12 more
TL;DR: The crystal structure of human NOP is reported, solved in complex with the peptide mimetic antagonist compound-24 (C-24), revealing atomic details of ligand–receptor recognition and selectivity and providing a new structural template for the design of NOP ligands.