V
Vera Kovaleva
Researcher at University of Helsinki
Publications - 11
Citations - 288
Vera Kovaleva is an academic researcher from University of Helsinki. The author has contributed to research in topics: Unfolded protein response & Tropomyosin receptor kinase B. The author has an hindex of 3, co-authored 8 publications receiving 87 citations.
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Journal ArticleDOI
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Plinio C. Casarotto,Mykhailo Girych,Senem Merve Fred,Vera Kovaleva,Rafael Moliner,Giray Enkavi,Caroline Biojone,Cecilia Cannarozzo,Madhusmita Pryiadrashini Sahu,Katja Kaurinkoski,Cecilia A. Brunello,Anna Steinzeig,Frederike Winkel,Sudarshan Patil,Stefan Vestring,Tsvetan Serchov,Cassiano R.A.F. Diniz,Cassiano R.A.F. Diniz,Liina Laukkanen,Iseline Cardon,Iseline Cardon,Iseline Cardon,Hanna Antila,Hanna Antila,Tomasz Róg,Timo Petteri Piepponen,Clive R. Bramham,Claus Normann,Sari E. Lauri,Mart Saarma,Ilpo Vattulainen,Eero Castrén +31 more
TL;DR: In this paper, the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and antidepressant responses, has a cholesterol-sensing function that mediates synaptic effects of cholesterol.
Journal ArticleDOI
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
Ave Eesmaa,Li-Ying Yu,Helka Göös,Kristofer Nõges,Vera Kovaleva,Maarit Hellman,Richard Zimmermann,Martin Jung,Perttu Permi,Markku Varjosalo,Päivi Lindholm,Mart Saarma +11 more
TL;DR: In this paper, the authors show that mesencephalic astrocyte-derived neurotrophic factor (MANF) promotes the survival of ER-stressed neurons in vitro as a general unfolded protein response (UPR) regulator, affecting several UPR pathways simultaneously.
Journal ArticleDOI
Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons.
Simona Selberg,Li-Ying Yu,Olesja Bondarenko,Esko Kankuri,Neinar Seli,Vera Kovaleva,Koit Herodes,Mart Saarma,Mati Karelson +8 more
TL;DR: In this article, a target-tailored development and biological characterization of small-molecule inhibitors of fat mass and obesity-associated protein (FTO), an RNA N6-methyladenosine (m6A) demethylase, is presented.
Posted ContentDOI
MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α
Vera Kovaleva,Li-Ying Yu,Larisa Ivanova,Jinhan Nam,Ave Eesmaa,Esa-Pekka Kumpula,Juha T. Huiskonen,Päivi Lindholm,Merja H. Voutilainen,Mati Karelson,Mart Saarma +10 more
TL;DR: The data reveal a novel mechanism of IRE1α regulation during ER stress and demonstrate the intracellular mode of action of MANF as a modulator of UPR and neuronal cell survival through the direct interaction with I RE1α and regulation of its activity.
Journal ArticleDOI
Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Rafael Moliner,Mykhailo Girych,Cecilia A. Brunello,Vera Kovaleva,Caroline Biojone,Giray Enkavi,Lina Antenucci,Erik F. Kot,Sergey A. Goncharuk,Katja Kaurinkoski,Senem Merve Fred,Lauri Elsilä,Sven Sakson,Cecilia Cannarozzo,Cassiano R.A.F. Diniz,Nina Seiffert,Anna Rubiolo,H M Haapaniemi,Elina I. Nagaeva,Tiina Öhman,Tomasz Róg,Esko Kankuri,Marçal Vilar,Markku Varjosalo,Esa R. Korpi,Perttu Permi,Konstantin S. Mineev,Mart Saarma,Ilpo Vattulainen,Plinio C. Casarotto,Eero Castrén +30 more
TL;DR: This article showed that LSD and psilocin directly bind to TrkB with affinities 1,000-fold higher than those for other antidepressants, and that psychedelics and antidepressants bind to distinct but partially overlapping sites within the transmembrane domain of TrkB dimers.