W
W. Peter Vandertop
Researcher at University of Amsterdam
Publications - 192
Citations - 8800
W. Peter Vandertop is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Subarachnoid hemorrhage & Glioma. The author has an hindex of 44, co-authored 165 publications receiving 7355 citations. Previous affiliations of W. Peter Vandertop include VU University Medical Center & VU University Amsterdam.
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Journal ArticleDOI
The prognostic IDH1 R132 mutation is associated with reduced NADP + -dependent IDH activity in glioblastoma
Fonnet E. Bleeker,Nadia A. Atai,Simona Lamba,A. Jonker,Denise Rijkeboer,Klazien S. Bosch,Wikky Tigchelaar,Dirk Troost,W. Peter Vandertop,Alberto Bardelli,Cornelis J.F. Van Noorden +10 more
TL;DR: It is concluded that NADPH production is hampered in glioblastoma with IDH1R132 mutation, and the low NADPH levels may sensitize gli oblastoma to irradiation and chemotherapy, thus explaining the prolonged survival of patients with mutated gliOBlastoma.
Journal ArticleDOI
Neurobehavioral Status and Health-Related Quality of Life in Newly Diagnosed High-Grade Glioma Patients
Martin Klein,Martin J B Taphoorn,Jan J. Heimans,Henk M. van der Ploeg,W. Peter Vandertop,Egbert F. Smit,Sieger Leenstra,Cees A. F. Tulleken,Willem Boogerd,José Belderbos,Wilmy Cleijne,Neil K. Aaronson +11 more
TL;DR: The general HRQOL of glioma patients is similar to that of patients with NSCLC, however, they suffer from a number of condition-specific neurologic and neuropsychologic problems that have a significant impact on their daily lives in the postsurgical period, before treatment with radiotherapy.
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In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
Shahryar E. Mir,Philip C. De Witt Hamer,Przemek M. Krawczyk,Leonora Balaj,An Claes,Johanna M. Niers,Johanna M. Niers,Angela A.G. van Tilborg,Aeilko H. Zwinderman,Dirk Geerts,Gertjan J.L. Kaspers,W. Peter Vandertop,Jacqueline Cloos,Bakhos A. Tannous,Pieter Wesseling,Jacob A. Aten,David P. Noske,Cornelis J.F. Van Noorden,Thomas Wurdinger,Thomas Wurdinger +19 more
TL;DR: It is demonstrated that WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells, and it is shown that the small-molecule inhibitor of Wee1 sensitizes gliOBlastoma to ionizing radiation in vivo.
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Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial
Sanne M. Dorhout Mees,Ale Algra,W. Peter Vandertop,Fop van Kooten,Hans A. J. M. Kuijsten,Jelis Boiten,Robert J. van Oostenbrugge,Rustam Al-Shahi Salman,Pablo M. Lavados,Gabriel J.E. Rinkel,Walter M. van den Bergh +10 more
TL;DR: The updated meta-analysis of seven randomised trials involving 2047 patients shows that magnesium is not superior to placebo for reduction of poor outcome after aneurysmal subarachnoid haemorrhage, therefore routine administration of magnesium cannot be recommended.