W
Weidong Wang
Researcher at National Institutes of Health
Publications - 86
Citations - 13635
Weidong Wang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chromatin remodeling & FANCM. The author has an hindex of 48, co-authored 78 publications receiving 12895 citations. Previous affiliations of Weidong Wang include VU University Amsterdam & Stanford University.
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Journal ArticleDOI
NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities
TL;DR: The results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin.
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Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.
Weidong Wang,Jacques Côté,Yutong Xue,Sharleen Zhou,Paul A. Khavari,Stephen R. Biggar,Christian Muchardt,Ganjam V. Kalpana,Stephen P. Goff,Moshe Yaniv,Jerry L. Workman,Gerald R. Crabtree +11 more
TL;DR: Purification of the SWI‐SNF2 homologs demonstrates that it is heterogeneous with respect to subunit composition, and certain cell lines completely lack BRG1 and hbrm, indicating that they are not essential for cell viability and that the mammalian SWI-SNF complex may be tailored to the needs of a differentiated cell type.
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Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling
Keji Zhao,Weidong Wang,Oliver J. Rando,Yutong Xue,Kristine M. Swiderek,Ann Kuo,Gerald R. Crabtree +6 more
TL;DR: It is found that antigen receptor signaling induces the rapid association of the BAF complex with chromatin, and membrane signals control the activity of the mammalian SWI/SNF or BAFcomplex and demonstrates a direct interface between signaling and chromatin regulation.
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Diversity and specialization of mammalian SWI/SNF complexes.
TL;DR: The observed similarity between mammalian BAF190, Baf170, BAF155, B AF60, and BAF47 and yeast SNF2/SWI2, SWI3, SWP73, and SNF5, respectively, underscores the similarity of the mammalian and yeast complexes.
Journal ArticleDOI
Superoxide Flashes in Single Mitochondria
Wang Wang,Huaqiang Fang,Linda Groom,Aiwu Cheng,Wanrui Zhang,Jie Liu,Xianhua Wang,Kaitao Li,Peidong Han,Ming Zheng,Jinhu Yin,Weidong Wang,Mark P. Mattson,Joseph P. Y. Kao,Edward G. Lakatta,Shey-Shing Sheu,Kunfu Ouyang,Ju Chen,Robert T. Dirksen,Heping Cheng +19 more
TL;DR: It is shown that individual mitochondria undergo spontaneous bursts of superoxide generation, termed "superoxide flashes", and proposed that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases.