Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling
Keji Zhao,Weidong Wang,Oliver J. Rando,Yutong Xue,Kristine M. Swiderek,Ann Kuo,Gerald R. Crabtree +6 more
TLDR
It is found that antigen receptor signaling induces the rapid association of the BAF complex with chromatin, and membrane signals control the activity of the mammalian SWI/SNF or BAFcomplex and demonstrates a direct interface between signaling and chromatin regulation.About:
This article is published in Cell.The article was published on 1998-11-25 and is currently open access. It has received 716 citations till now. The article focuses on the topics: Chromatin remodeling & Chromatin structure remodeling (RSC) complex.read more
Citations
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The Biology of Chromatin Remodeling Complexes
TL;DR: This work addresses many aspects of remodeler biology: their targeting, mechanism, regulation, shared and unique properties, and specialization for particular biological processes.
Journal ArticleDOI
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
Cigall Kadoch,Diana C. Hargreaves,Courtney Hodges,Laura Elias,Lena Ho,Jeff Ranish,Gerald R. Crabtree +6 more
TL;DR: It is demonstrated that mSWI/SNF is the most frequently mutated chromatin-regulatory complex (CRC) in human cancer, exhibiting a broad mutation pattern, similar to that of TP53, and proper functioning of polymorphic BAF complexes may constitute a major mechanism of tumor suppression.
Journal ArticleDOI
Involvement of the tip60 histone acetylase complex in dna repair and apoptosis
Tsuyoshi Ikura,Vasily Ogryzko,Mikhail Grigoriev,Regina Groisman,Jin Wang,Masami Horikoshi,Ralph Scully,Jun Qin,Yoshihiro Nakatani,Yoshihiro Nakatani +9 more
TL;DR: Results indicate that the histone acetylase TIP60-containing complex plays a role in DNA repair and apoptosis, suggesting a defect in the cells' ability to signal the existence of DNA damage to the apoptotic machinery.
Journal ArticleDOI
Molecular Mechanisms RegulatinG Th1 Immune Responses
TL;DR: The mechanisms that control lineage commitment to the Th1 phenotype are discussed, and the basic pathways leading to Th1 differentiation can now be understood in in vitro and a number of infection and disease models.
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Nuclear speckles: a model for nuclear organelles.
Angus I. Lamond,David L. Spector +1 more
TL;DR: Speckles are subnuclear structures that are enriched in pre-messenger RNA splicing factors and are located in the interchromatin regions of the nucleoplasm of mammalian cells, and can cycle continuously between speckles and other nuclear locations, including active transcription sites.
References
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TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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Contingent genetic regulatory events in T lymphocyte activation
TL;DR: The view is put forth that signals originating from separate cell membrane receptors are integrated at the level of the responsive gene and initiate a contingent series of gene activations that bring about proliferation and impart immunologic function.