W
Wenhui Wang
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 29
Citations - 881
Wenhui Wang is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 9, co-authored 24 publications receiving 605 citations. Previous affiliations of Wenhui Wang include Case Western Reserve University & Shandong University.
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Journal ArticleDOI
Drug repositioning by integrating target information through a heterogeneous network model
TL;DR: This paper proposes a computational framework based on a heterogeneous network model and applied the approach on drug repositioning by using existing omics data about diseases, drugs and drug targets and shows that the proposed approach significantly outperforms several recent approaches.
Journal ArticleDOI
Gut microbiota density influences host physiology and is shaped by host and microbial factors
Eduardo J. Contijoch,Graham J. Britton,Chao Yang,Ilaria Mogno,Zhihua Li,Ruby Ng,Sean R. Llewellyn,Sheela Hira,Crystal H Johnson,Keren M. Rabinowitz,Keren M. Rabinowitz,Revital Barkan,Iris Dotan,Iris Dotan,Robert Hirten,Shih Chen Fu,Yuying Luo,Nancy Yang,Tramy Luong,Philippe R Labrias,Sergio A. Lira,Inga Peter,Ari Grinspan,Jose C. Clemente,Roman Kosoy,Seunghee Kim-Schulze,Xiaochen Qin,Anabella Castillo,Amanda Hurley,Ashish Atreja,Jason Rogers,Farah Fasihuddin,Merjona Saliaj,Amy Nolan,Pamela Reyes-Mercedes,Carina Rodriguez,Sarah Aly,Kenneth Santa-Cruz,Lauren A. Peters,Mayte Suárez-Fariñas,R Huang,Ke Hao,Jun Zhu,Bin Zhang,Bojan Losic,Haritz Irizar,Won-Min Song,Antonio Fabio Di Narzo,Wenhui Wang,Benjamin L. Cohen,Christopher J. DiMaio,David A. Greenwald,Steven H. Itzkowitz,Aimee L. Lucas,James F. Marion,Elana Maser,Ryan C. Ungaro,Steven Naymagon,Joshua Novak,Brijen Shah,Thomas A. Ullman,Peter H. Rubin,James F. George,Peter Legnani,Shannon Telesco,Joshua R. Friedman,Carrie Brodmerkel,S Plevy,Judy H. Cho,Jean-Frederic Colombel,Eric E. Schadt,Carmen Argmann,Marla Dubinsky,Andrew Kasarskis,Bruce E. Sands,Jeremiah J. Faith +75 more
TL;DR: Understanding the interplay between microbiota and disease in terms of microbiota density, host carrying capacity, and microbiota fitness provide new insights into microbiome structure and microbiome targeted therapeutics.
Proceedings ArticleDOI
Drug target predictions based on heterogeneous graph inference
Wenhui Wang,Sen Yang,Jing Li +2 more
TL;DR: A network based computational approach for novel drug and target association predictions that incorporates known drug-target interactions as well as drug-drug and target-target similarities is proposed and can greatly improve novel target predictions.
Journal ArticleDOI
Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease.
Mayte Suárez-Fariñas,Minami Tokuyama,Gabrielle Wei,Ruiqi Huang,Alexandra E. Livanos,Divya Jha,Anais Levescot,Anais Levescot,Haritz Irizar,Roman Kosoy,Sascha Cording,Sascha Cording,Wenhui Wang,Bojan Losic,Ryan C. Ungaro,Antonio Di’Narzo,Gustavo Martinez-Delgado,Maria Suprun,Michael J. Corley,Aleksandar Stojmirović,Sander M. Houten,Lauren A. Peters,Mark Curran,Carrie Brodmerkel,Jacqueline Perrigoue,Joshua R. Friedman,Ke Hao,Eric E. Schadt,Jun Zhu,Huaibin M. Ko,Judy H. Cho,Marla Dubinsky,Bruce E. Sands,Lishomwa C. Ndhlovu,Nadine Cerf-Bensusan,Andrew Kasarskis,Jean-Frederic Colombel,Noam Harpaz,Carmen Argmann,Saurabh Mehandru +39 more
TL;DR: A novel appreciation of the confluence of CO VID-19- and IBD-associated inflammation is generated and mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19 are provided.
Journal ArticleDOI
In Silico Gene Prioritization by Integrating Multiple Data Sources
Yixuan Chen,Wenhui Wang,Yingyao Zhou,Robert W. Shields,Sumit K. Chanda,Robert C. Elston,Jing Li,Jing Li +7 more
TL;DR: This paper proposes an expandable framework for gene prioritization that can integrate multiple heterogeneous data sources by taking advantage of a unified graphic representation and shows that this approach consistently outperforms other two state of the art programs.