William A. Blattner

TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.

TL;DR: The diversity of tumor types in this syndrome suggests pathogenetic mechanisms which differ from hereditary cancers arising in single organs or tissues and laboratory markers are needed to identify high-risk individuals and families and to provide insights into susceptibility mechanisms that may be shared by a wide variety of cancers.

TL;DR: The p53 gene in a family affected by Li–Fraumeni syndrome, a rare autosomal dominant syndrome characterized by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites, had the same point mutation in codon 245 (GGC→GAC), which leads to substitution of aspartic acid for glycine in one of the regions identified as a frequent target of point mutations in p53.

TL;DR: An HLA profile was produced that predicted time from HIV–1 infection to the onset of AIDS and support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.

TL;DR: Levels of HIV-1 RNA at delivery and prenatal antiretroviral therapy were independently associated with transmission and the protective effect of therapy increased with the complexity and duration of the regimen.