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William A. Blattner
Researcher at University of Maryland, Baltimore
Publications - 345
Citations - 26953
William A. Blattner is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Population & Virus. The author has an hindex of 80, co-authored 345 publications receiving 26023 citations. Previous affiliations of William A. Blattner include RTI International & Boston University.
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Journal ArticleDOI
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Brandon F. Keele,Elena E. Giorgi,Elena E. Giorgi,Jesus F. Salazar-Gonzalez,Julie M. Decker,Kimmy T. Pham,Maria G. Salazar,Chuanxi Sun,Truman Grayson,Shuyi Wang,Hui Li,Xiping Wei,Chunlai Jiang,Jennifer L. Kirchherr,Feng Gao,Jeffery A. Anderson,Li Hua Ping,Ronald Swanstrom,Georgia D. Tomaras,William A. Blattner,Paul A. Goepfert,J. Michael Kilby,Michael S. Saag,Eric Delwart,Michael P. Busch,Myron S. Cohen,David C. Montefiori,Barton F. Haynes,Brian Gaschen,Gayathri Athreya,Ha Y. Lee,Natasha T. Wood,Cathal Seoighe,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +39 more
TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
Journal Article
A cancer family syndrome in twenty-four kindreds.
Frederick P. Li,Joseph F. Fraumeni,John J. Mulvihill,William A. Blattner,Margaret G. Dreyfus,Margaret A. Tucker,Robert W. Miller +6 more
TL;DR: The diversity of tumor types in this syndrome suggests pathogenetic mechanisms which differ from hereditary cancers arising in single organs or tissues and laboratory markers are needed to identify high-risk individuals and families and to provide insights into susceptibility mechanisms that may be shared by a wide variety of cancers.
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Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome.
TL;DR: The p53 gene in a family affected by Li–Fraumeni syndrome, a rare autosomal dominant syndrome characterized by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites, had the same point mutation in codon 245 (GGC→GAC), which leads to substitution of aspartic acid for glycine in one of the regions identified as a frequent target of point mutations in p53.
Journal ArticleDOI
Influence of combinations of human major histocompatibility complex genes on the course of HIV–1 infection
Richard A. Kaslow,Mary Carrington,Raymond J. Apple,Lawrence P. Park,Alvaro Muñoz,A. J. Saah,James J. Goedert,Cheryl A. Winkler,Stephen J. O'Brien,Charles R. Rinaldo,Roger Detels,William A. Blattner,John P. Phair,Henry A. Erlich,Dean L. Mann +14 more
TL;DR: An HLA profile was produced that predicted time from HIV–1 infection to the onset of AIDS and support current theory about control of antigen processing by HLA genes and have implications for immunopathogenesis of HIV-1 and other infections.
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Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission.
Ellen R. Cooper,Manhattan Charurat,Lynne M. Mofenson,I. Celine Hanson,Jane Pitt,Clemente Diaz,Karen C. Hayani,Edward Handelsman,Vincent Smeriglio,Rodney Hoff,William A. Blattner +10 more
TL;DR: Levels of HIV-1 RNA at delivery and prenatal antiretroviral therapy were independently associated with transmission and the protective effect of therapy increased with the complexity and duration of the regimen.