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William C. Blackwelder
Researcher at University of Maryland, Baltimore
Publications - 66
Citations - 7792
William C. Blackwelder is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Vaccination & Population. The author has an hindex of 32, co-authored 66 publications receiving 6529 citations. Previous affiliations of William C. Blackwelder include University of Maryland Marlene and Stewart Greenebaum Cancer Center.
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Journal ArticleDOI
Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study.
Karen L. Kotloff,James P. Nataro,William C. Blackwelder,Dilruba Nasrin,Tamer H. Farag,Sandra Panchalingam,Yukun Wu,Samba O. Sow,Dipika Sur,Robert F. Breiman,Abu Syed Golam Faruque,Anita K. M. Zaidi,Debasish Saha,Pedro L. Alonso,Boubou Tamboura,Doh Sanogo,Uma Onwuchekwa,Byomkesh Manna,Thandavarayan Ramamurthy,Suman Kanungo,John B. Ochieng,Richard Omore,Joseph Oundo,Anowar Hossain,Sumon Kumar Das,Shahnawaz Ahmed,Shahida Qureshi,Farheen Quadri,Richard A. Adegbola,Richard A. Adegbola,Martin Antonio,M. Jahangir Hossain,Adebayo Akinsola,Inacio Mandomando,Tacilta Nhampossa,Sozinho Acácio,Kousick Biswas,Ciara E. O’Reilly,Eric D. Mintz,Lynette Y. Berkeley,Lynette Y. Berkeley,Khitam Muhsen,Halvor Sommerfelt,Halvor Sommerfelt,Roy M. Robins-Browne,Myron M. Levine +45 more
TL;DR: Interventions targeting five pathogens can substantially reduce the burden of moderate-to-severe diarrhoea and suggest new methods and accelerated implementation of existing interventions (rotavirus vaccine and zinc) are needed to prevent disease and improve outcomes.
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Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study
Jie Liu,James A Platts-Mills,Jane Juma,Furqan Kabir,Joseph Nkeze,Catherine Okoi,Darwin J. Operario,Jashim Uddin,Shahnawaz Ahmed,Pedro L. Alonso,Martin Antonio,Stephen M. Becker,William C. Blackwelder,Robert F. Breiman,Abu Syed Golam Faruque,Barry S. Fields,Jean Gratz,Rashidul Haque,Anowar Hossain,M. Jahangir Hossain,Sheikh Jarju,Farah Naz Qamar,Najeeha Talat Iqbal,Brenda Kwambana,Inacio Mandomando,Timothy L. McMurry,Caroline Ochieng,John B. Ochieng,Melvin Ochieng,Clayton Onyango,Sandra Panchalingam,Adil Kalam,Fatima Aziz,Shahida Qureshi,Thandavarayan Ramamurthy,James H Roberts,Debasish Saha,Samba O. Sow,Suzanne Stroup,Dipika Sur,Boubou Tamboura,Mami Taniuchi,Sharon M. Tennant,Deanna Toema,Yukun Wu,Anita K. M. Zaidi,James P. Nataro,Karen L. Kotloff,Myron M. Levine,Eric R. Houpt +49 more
TL;DR: A quantitative molecular diagnostic approach improved population-level and case-level characterisation of the causes of diarrhoea and indicated a high burden of disease associated with six pathogens, for which targeted treatment should be prioritised.
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Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans.
John J. Treanor,Bethanie E. Wilkinson,Feda Masseoud,Jean Hu-Primmer,Rosalyn Battaglia,Diane O'Brien,Mark Wolff,Gina Rabinovich,William C. Blackwelder,Jacqueline M. Katz +9 more
TL;DR: It is suggested that baculovirus-expressed H5 HA can induce functional antibody in individuals who have not had prior exposure to H5 viruses, but that further studies to improve the immunogenicity of the vaccine are needed.
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In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes.
Birke Bartosch,Jens Bukh,Jean-Christophe Meunier,Christelle Granier,Ronald E. Engle,William C. Blackwelder,Suzanne U. Emerson,François-Loïc Cosset,Robert H. Purcell +8 more
TL;DR: A neutralization assay based on the neutralization of pseudotyped murine retrovirus constructs bearing HCV envelope glycoproteins on their surface was applied to well characterized clinical samples from HCV-infected patients and chimpanzees, confirmed the existence of neutralizing Ab to HCV, and validated most previously reported neutralizations of the virus.
Journal ArticleDOI
Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer
Aaron P. Rapoport,Edward A. Stadtmauer,Nicole A. Aqui,Ashraf Badros,Julio Cotte,Lisa Chrisley,Elizabeth Veloso,Zhaohui Zheng,Sandra Westphal,Rebecca Mair,Nina Chi,Bashi Ratterree,Mary Francis Pochran,Sabrina Natt,Joanne Hinkle,C Sickles,Ambika Sohal,Kathleen Ruehle,Christian Lynch,Lei Zhang,David L. Porter,Selina M. Luger,Chuanfa Guo,Hong-Bin Fang,William C. Blackwelder,Kim Hankey,Dean L. Mann,Robert R. Edelman,Carl E. Frasch,Bruce L. Levine,Alan S. Cross,Carl H. June +31 more
TL;DR: Combination immunotherapy consisting of a single early post-transplant infusion of in vivo vaccine-primed and ex vivo costimulated autologous T cells followed by post-Transplant booster immunizations improved the severe immunodeficiency associated with high-dose chemotherapy and led to the induction of clinically relevant immunity in adults within a month after transplantation.