William C. Hahn

TL;DR: The data support a model in which ST promotes survival through constitutive integrin signaling, src phosphorylation, and nuclear factor κB activation, while inhibiting cell-cell adhesion pathways.

TL;DR: Experimental models derived from the manipulation of oncogenes, tumor suppressor genes and telomerase provide useful platforms to delineate pathways involved in cell transformation, to connect specific cancer-associated mutations with particular cancer phenotypes and to discover and validate new targets for therapeutic development.

TL;DR: Observations implicate Nek4 as a novel regulator of replicative senescence and the response to double-stranded DNA damage.

TL;DR: It is found that insertion of this cassette suppressed RMRP expression, and it was unable to obtain viable mice homozygous for the R MRP conditional allele, indicating that RMRp is essential for early embryonic development.

TL;DR: The results have important implications for planned and ongoing prostate cancer clinical trials and suggest that patients with tumor ATM alterations may be more likely to benefit from ATR inhibitor than PARP inhibitor therapy.