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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
Lab-Cell Biology And Signaling
Noriyuki Kijima,Naoki Hosen,Naoki Kagawa,Naoya Hashimoto,Yasuyoshi Chiba,Manabu Kinoshita,Haruo Sugiyama,Toshiki Yoshimine,Young Zoon Kim,Kyu Hong Kim,Eun Hee Lee,Bin Hu,Hosung Sim,Nandhu Mohan,Paula Agudelo-Garcia,Gerard Nuovo,Susan Cole,Mariano S. Viapiano,Braden C. McFarland,Suk W. Hong,Rajani Rajbhandari,George B. Twitty,G. Kenneth Gray,Hao Yu,Catherine P. Langford,G. Yancey Gillespie,Etty N. Benveniste,Susan Nozell,Ryan Nitta,Siddhartha Mitra,Timothy T. Bui,Gordon Li,Jessian L. Munoz,Vivian Rodriguez-Cruz,Pranela Rameshwar,Wendy L. See,Joydeep Mukherjee,Kevin M. Shannon,Russell O. Pieper,Desiree H. Floyd,Aizhen Xiao,Benjamin Purow,Iris Lavon,Daniel Zrihan,Miri Refael,Ariel Bier,Tamar Canello,Tali Siegal,Avital Granit,Qing Xie,Xuanchun Wang,Ye Gong,Yin Mao,Xiancheng Chen,Liangfu Zhou,Sze Xian Lee,Adrian Tunkyi,Eric T. Wong,Kenneth D. Swanson,Kailiang Zhang,Luyue Chen,Junxia Zhang,Zhendong Shi,Lei Han,Peiyu Pu,Chunsheng Kang,Won Ho Cho,Daisuke Ogawa,Jakub Godlewski,Agnieszka Bronisz,E. Antonio Chiocca,Dana A M Mustafa,Anieta M. Sieuwerts,Marcel Smid,Vanja de Weerd,John W.M. Martens,John A. Foekens,Johan M. Kros,Jingyu Zhang,Colin Craig McCulloch,Jeremy Graff,Yunxia Sui,Sean Richard Dinn,Yuchi Huang,Qing Li,Ginty Fiona,Hiroshi Nakashima,Lina Leiss,Ivana Manini,Per Øyvind Enger,Chunzhang Yang,Rajiv Iyer,Albert Cheung Hoi Yu,Siqi Li,Barbara Ikejiri,Zhengping Zhuang,Russell Lonser,Tarik F. Massoud,Ramasamy Paulmurugan,Sanjiv S. Gambhir,Marsha J. Merrill,Michael Sun,Masako Chen,Nancy A. Edwards,Sharon B. Shively,Russell R. Lonser,Gilson Baia,Otavia L. Caballero,Brent A. Orr,Anita Lal,Janelle S. Ho,Cynthia Cowdrey,Tarik Tihan,Christian Mawrin,Gregory J. Riggins,Dan Lu,Charles Leo,Helen Wheeler,Kerrie L. McDonald,Alexander Schulte,Svenja Zapf,Malgorzata Stoupiec,Katharina Kolbe,Sabine Riethdorf,Manfred Westphal,Katrin Lamszus,Marco Timmer,Gabriele Röhn,Arend Koch,Roland Goldbrunner,Rosamaria Ruggieri,Issai Vanan,Zhiwan Dong,Jann N. Sarkaria,Nhan L. Tran,Michael E. Berens,Marc Symons,Farjana B. Rowther,Timothy Dawson,Kate Ashton,John L. Darling,Tracy Warr,Masahiko Okamoto,Kamalakannan Palanichamy,Nicolaus Gordon,Disha Patel,Steve Walston,Thirumoorthy Krishanan,Arnab Chakravarti,Juliya Kalinina,Anne Carroll,Liya Wang,Qiqi Yu,Danny E. Mancheno,Shaoxiong Wu,Frank Liu,Jun Ahn,Miao He,Hui Mao,Erwin G. Van Meir,Waldemar Debinski,Oscar Gonzales,Amanda Beauchamp,Denise M. Gibo,Darren F. Seals,Maria Carmela Speranza,Veronique Frattini,Dimos Kapetis,Federica Pisati,Marica Eoli,Serena Pellegatta,Gaetano Finocchiaro,Zaynah Maherally,James R. Smith,Geoffrey J. Pilkington,Wen Zhu,Qiwei Wang,Paul A. Clark,Sung-Sen Yang,Shih-Hua Lin,Kristopher T. Kahle,John S. Kuo,Dandan Sun,Mohammad B. Hossain,Nahir Cortes-Santiago,Anupama Gururaj,Jonathan Thomas,Konrad Gabrusiewicz,Joy Gumin,Enric Xipell,Frederick Lang,Juan Fueyo,W.K. Alfred Yung,Candelaria Gomez-Manzano,Nicholas J Cook,Johnathan E. Lawrence,Richard A. Rovin,Robert J. Belton,Robert J. Winn,Sara Ferluga,Sok-Hyong Lee,Fatima W. Khwaja,Abdessamad Zerrouqi,Narra S. Devi,Kristen L. Drucker,Hae Kyung Lee,Susan Finniss,Simona Cazacu,Laila M. Poisson,Cunli Xiang,Sandra A. Rempel,Tom Mikkelsen,Chaya Brodie,John Shen,Rajappa S. Kenchappa,J. Gerardo Valadez,Michael K. Cooper,Bruce D. Carter,Peter A. Forsyth,Jun Sung Lee,Anat Erdreich-Epstein,Hae-Ri Song,Samuel Lawn,Rajappa Kenchappa,Peter A. Forsyth,Kah Jing Lim,Eli E. Bar,Charles G. Eberhart,Michael Blough,Mohammad AlNajjar,Charles Chesnelong,Samuel Weiss,Jennifer A. Chan,Gregory Cairncross,Jill Wykosky,Webster Cavenee,Frank Furnari,Kristine E. Brown,Stephen T. Keir,John Sampson,Darell D. Bigner,Madan M. Kwatra,Rama Prasadarao Kotipatruni,Dinesh Thotala,Jerry J. Jaboin,Tiffany E. Taylor,Anna C. Schinzel,William C. Hahn,Webster K. Cavenee,Frank B. Furnari,Gurpreet S. Kapoor,Luke Macyszyn,Yingtao Bi,Heather Fetting,Harish Poptani,Ranjit Ittyerah,Ramana V. Davuluri,Donald M. O'Rourke,Kenneth L. Pitter,Amira Hosni-Ahmed,Kara Colevas,Eric C. Holland,Terreia S. Jones,Anshu Malhotra,Chad R. Potts,Africa Fernandez-Lopez,Anna Kenney,Shi Yuan Cheng,Haizhong Feng,Bo Hu,Michael J. Jarzynka,Yanxin Li,Susan Keezer,Terrance Grant Johns,Ronald L. Hamilton,Kristiina Vuori,Ryo Nishikawa,Tim R. Fenton,Tao Cheng,Andrei M. Mikheev,Svetlana A. Mikheeva,John R. Silber,Philip J. Horner,Robert C. Rostomily,Elizabeth S. Henson,Michelle Brown,David D. Eisenstat,Spencer B. Gibson,Richard L. Price,Jieun Song,Katherine Bingmer,Michael Oglesbee,Charles H. Cook,Chang-Hyuk Kwon,Tran T. Nguyen,E.A. Chiocca,Walter J. Lukiw,Frank Culicchia,Brandon M. Jones,Yuhai Zhao,Surjyadipta Bhattacharjee +300 more
Posted ContentDOI
Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation
P. Bala,Jonathan P. Rennhack,Daulet Aitymbayev,Clare Morris,Sydney M. Moyer,Gina N. Duronio,Paul Doan,Zhixin Li,Xiaoyan Liang,Jason L. Hornick,Matthew B. Yurgelun,William C. Hahn,Nilay Sethi +12 more
TL;DR: The authors showed that aberrant cell state plasticity mediated by unabated regenerative activity and developmental reprogramming precedes cancer development in colorectal epithelial cells, and demonstrated that impaired differentiation is a conserved event preceding cancer development.
Posted ContentDOI
Expanding discovery from cancer genomes by integrating protein network analyses with in vivo tumorigenesis assays
Heiko Horn,Michael S. Lawrence,Candace R. Chouinard,Yashaswi Shrestha,Jessica Xin Hu,Elizabeth Worstell,Emily Shea,Nina Ilic,Eejung Kim,Atanas Kamburov,Alireza Kashani,Joshua D. Campbell,William C. Hahn,Jesse S. Boehm,Gad Getz,Kasper Lage +15 more
TL;DR: A robust statistic (NetSig) that integrates protein interaction networks and data from 4,742 tumor exomes is developed and used to accurately classify known driver genes in 60% of tested tumor types and to predict 62 new candidates.
Journal ArticleDOI
HOXA9 Is a Novel Therapeutic Target in Multiple Myeloma.
Michael A Chapman,Jean-Philippe Brunet,Jonathan J Keats,Angela Baker,Mazhar Adli,Anna C. Schinzel,Gregory J. Ahmann,Harview Christina,Anna Moore,Vijayalakshmi Shanmugam,Louise M. Perkins,Daniel Auclair,William C. Hahn,Bradley E. Bernstein,Leif Bergsagel,Rafael Fonseca,John D. Carpten,Jeffrey M. Trent,Todd R. Golub +18 more
TL;DR: In this article, HOXA9 expression was found to be essential for survival of multiple myeloma (MM) cells, and the authors used an outlier statistical approach to identify the top candidate gene for further investigation.
Journal ArticleDOI
Functional Genomic Landscape of Genes with Recurrent Mutations in Multiple Myeloma
Ricardo De Matos Simoes,Ricardo De Matos Simoes,Ryosuke Shirasaki,Ryosuke Shirasaki,Huihui Tang,Huihui Tang,Michal Sheffer,Michal Sheffer,Olga Dashevsky,Olga Dashevsky,Sara Gandolfi,Sara Gandolfi,Eugen Dhimolea,Eugen Dhimolea,Megan Bariteau,Megan Bariteau,Jonathan D. Licht,Brian J. Glassner,Brian J. Glassner,Richard W.J. Groen,Richard W.J. Groen,Joan Levy,Daniel Auclair,Francisca Vazquez,Aviad Tsherniak,William C. Hahn,William C. Hahn,Aedín C. Culhane,Constantine S. Mitsiades,Constantine S. Mitsiades +29 more
TL;DR: The results highlight the value of interpreting results from next generation sequencing studies in the context of information provided by the genome scale by use of functional genomic characterization of available cell line models.