William C. Hahn

TL;DR: Findings reveal a differential dependency of clear cell ovarian cancers on EGLN1, thus identifying E GLN1 as a potential therapeutic target in clear cell Ovarian cancer patients.

TL;DR: In this article, the authors performed genome-scale CRISPR-Cas9-based gene editing studies and found that myeloma cell resistance to degraders of different targets (BET bromodomain proteins, CDK9) and operating through CRBN (degronimids) or VHL is primarily mediated by prevention of, rather than adaptation to, breakdown of the target oncoprotein; and this involves loss of function of the cognate E3 ligase or interactors/regulators of the respective cullin-RING ligase (C

TL;DR: A zinc-finger nuclease translocation reporter is developed and a model in whichPARP3 suppresses G4 DNA and facilitates DNA repair by multiple pathways is proposed, which finds that PARP3 regulates G quadruplex DNA in response to DNA damage, which suppresses repair by nonhomologous end-joining and homologous recombination.

TL;DR: Gene silencing of two members of the JAK family increased the susceptibility of a variety of tumor cell types to NK-mediated lysis and induced increased secretion of IFN-γ by NK cells.

TL;DR: FGFR2 EIDs are revealed as an alternative mechanism of FGFR2 activation in IHCC that predict sensitivity to FGFR inhibitors in the clinic and reveal the genomic landscape by anatomic site within the biliary tree.