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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
Cancer research needs a better map.
Jesse S. Boehm,Mathew J. Garnett,David J. Adams,Hayley E. Francies,Todd R. Golub,William C. Hahn,Francesco Iorio,James M. McFarland,Leopold Parts,Francisca Vazquez +9 more
TL;DR: It is time to move beyond tumour sequencing data to identify vulnerabilities in cancers as discussed by the authors, and this is the direction we should take in this paper. But it is difficult to do so.
Journal ArticleDOI
High throughput mass spectrometry-based mutation profiling of primary uveal melanoma
Anthony B. Daniels,Joo Eun Lee,Joo Eun Lee,Laura E. MacConaill,Laura E. MacConaill,Emanuele Palescandolo,Emanuele Palescandolo,Paul Van Hummelen,Paul Van Hummelen,S. M. Adams,Margaret M. DeAngelis,William C. Hahn,Evangelos S. Gragoudas,J. William Harbour,Levi A. Garraway,Ivana K. Kim +15 more
TL;DR: The vast majority of primary large uveal melanomas harbor mutually-exclusive mutations in GNAQ or GNA11, but very rarely have the oncogenic mutations that are reported commonly in other cancers.
Journal ArticleDOI
Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer.
Sylvan C. Baca,Sylvan C. Baca,David Y. Takeda,Ji-Heui Seo,Justin H. Hwang,Sheng-Yu Ku,Rand Arafeh,Taylor E. Arnoff,Supreet Agarwal,Connor Bell,Edward P. O’Connor,Xintao Qiu,Sarah Abou Alaiwi,Rosario I. Corona,Marcos A. S. Fonseca,Claudia Giambartolomei,Claudia Giambartolomei,Paloma Cejas,Klothilda Lim,Monica He,Anjali V. Sheahan,Amin Nassar,Jacob E. Berchuck,Lisha G. Brown,Holly M. Nguyen,Ilsa Coleman,Arja Kaipainen,Navonil De Sarkar,Peter S. Nelson,Colm Morrissey,Keegan Korthauer,Mark Pomerantz,Leigh Ellis,Leigh Ellis,Bogdan Pasaniuc,Kate Lawrenson,Kathleen Kelly,Amina Zoubeidi,Amina Zoubeidi,William C. Hahn,William C. Hahn,Himisha Beltran,Henry W. Long,Myles Brown,Eva Corey,Matthew L. Freedman,Matthew L. Freedman +46 more
TL;DR: In this paper, the epigenomic basis of resistance to targeted therapy in cancer was investigated by profiling histone modifications in NEPC and PRAD patient-derived xenografts (PDXs) using chromatin immunoprecipitation and sequencing.
Journal ArticleDOI
MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Kris C. Wood,David J. Konieczkowski,David J. Konieczkowski,Cory M. Johannessen,Cory M. Johannessen,Jesse S. Boehm,Pablo Tamayo,Olga B Botvinnik,Jill P. Mesirov,William C. Hahn,William C. Hahn,David E. Root,Levi A. Garraway,Levi A. Garraway,David M. Sabatini +14 more
TL;DR: The MicroSCALE platform described here may enable new classes of large-scale, resource-efficient screens that were not previously feasible, including those involving combinations of cell lines, perturbations, and assay outputs or those involving limited numbers of cells and limited or expensive reagents.
Journal ArticleDOI
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
Jong Wook Kim,Jong Wook Kim,Jong Wook Kim,Omar O. Abudayyeh,Huwate Yeerna,Chen-Hsiang Yeang,Chen-Hsiang Yeang,Michelle Stewart,Russell W. Jenkins,Shunsuke Kitajima,David J. Konieczkowski,David J. Konieczkowski,Kate Medetgul-Ernar,Taylor B. Cavazos,Clarence K. Mah,Stephanie Ting,Eliezer M. Van Allen,Eliezer M. Van Allen,Ofir Cohen,Ofir Cohen,John H McDermott,Emily Damato,Andrew J. Aguirre,Andrew J. Aguirre,Andrew J. Aguirre,Jonathan Liang,Arthur Liberzon,Gabriella Alexe,John G. Doench,Mahmoud Ghandi,Francisca Vazquez,Francisca Vazquez,Barbara A. Weir,Aviad Tsherniak,Aravind Subramanian,Karina Meneses-Cime,Jason Park,Paul A. Clemons,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,David Thomas,Jesse S. Boehm,David A. Barbie,David A. Barbie,William C. Hahn,Jill P. Mesirov,Jill P. Mesirov,Pablo Tamayo,Pablo Tamayo +49 more
TL;DR: The results show that the Onco-GPS is an effective approach to explore the complex landscape of oncogenic cellular states across cancers, and an analytic framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms.