W
William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
Papers
More filters
Journal ArticleDOI
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley,Barbara A. Weir,Barbara A. Weir,Francisca Vazquez,Francisca Vazquez,Pablo Tamayo,Justine A. Scott,Scott F. Rusin,Alexandra East-Seletsky,Levi D. Ali,William F.J Gerath,Sarah E Pantel,Patrick H. Lizotte,Guozhi Jiang,Jessica Hsiao,Aviad Tsherniak,Elizabeth Dwinell,Simon Aoyama,Michael Okamoto,William F. Harrington,Ellen Gelfand,Thomas M Green,Mark J Tomko,Shuba Gopal,Terence C. Wong,Hubo Li,Sara Howell,Nicolas Stransky,Ted Liefeld,Dongkeun Jang,Jonathan Bistline,Barbara Hill Meyers,Scott A. Armstrong,Kenneth C. Anderson,Kimberly Stegmaier,Kimberly Stegmaier,Michael R. Reich,David Pellman,Jesse S. Boehm,Jill P. Mesirov,Todd R. Golub,David E. Root,William C. Hahn +42 more
TL;DR: This dataset facilitates the linkage of genetic dependencies with specific cellular contexts (e.g., gene mutations or cell lineage) and developed and provided a bioinformatics tool to identify linear and nonlinear correlations between these features.
Journal ArticleDOI
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Kenkichi Masutomi,Richard Possemato,Judy M. Y. Wong,Jennifer L. Currier,Zuzana Tothova,Judith Manola,Shridar Ganesan,Peter M. Lansdorp,Kathleen Collins,William C. Hahn,William C. Hahn +10 more
TL;DR: In this article, the authors show that the human telomerase reverse transcriptase (hTERT) expression abrogates the cellular response to DNA double strand breaks, resulting in increased radiosensitivity, diminished capacity for DNA repair, and fragmented chromosomes.
Journal ArticleDOI
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas
Priscilla K. Brastianos,Amaro Taylor-Weiner,Peter E. Manley,Robert T. Jones,Dora Dias-Santagata,Aaron R. Thorner,Michael S. Lawrence,Fausto J. Rodriguez,Lindsay A. Bernardo,Laura Schubert,Ashwini Sunkavalli,Nick Shillingford,Monica L. Calicchio,Hart G.W. Lidov,Hala Taha,Maria Martinez-Lage,Mariarita Santi,Phillip B. Storm,John Y K Lee,James N. Palmer,Nithin D. Adappa,R. Michael Scott,Ian F. Dunn,Edward R. Laws,Chip Stewart,Keith L. Ligon,Mai P. Hoang,Paul Van Hummelen,William C. Hahn,David N. Louis,Adam C. Resnick,Mark W. Kieran,Gad Getz,Sandro Santagata +33 more
TL;DR: Using whole-exome sequencing, mutations in CTNNB1 (β-catenin) and BRAF were identified in nearly all adamantinomatous and papillary craniopharyngiomas examined and clonal in each tumor subtype, and these findings have important implications for the diagnosis and treatment of these neoplasms.
Journal ArticleDOI
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Yoshiko Maida,Mami Yasukawa,Miho Furuuchi,Timo Lassmann,Richard Possemato,Naoko Okamoto,Vivi Kasim,Yoshihide Hayashizaki,William C. Hahn,William C. Hahn,Kenkichi Masutomi +10 more
TL;DR: It is shown that TERT interacting with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage–hair hypoplasia, identifies a mammalian RdRP composed of TERT in complex with RMRP.
Journal ArticleDOI
Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer
Toshiro Migita,Stacey Ruiz,Alessandro Fornari,Michelangelo Fiorentino,Carmen Priolo,Giorgia Zadra,Fumika Inazuka,Chiara Grisanzio,Emanuele Palescandolo,Eyoung Shin,Christopher Fiore,Wanling Xie,Andrew L. Kung,Phillip G. Febbo,Aravind Subramanian,Lorelei A. Mucci,Jing Ma,Sabina Signoretti,Meir J. Stampfer,William C. Hahn,Stephen P. Finn,Massimo Loda +21 more
TL;DR: FASN can act as a prostate cancer oncogene in the presence of AR and that FASN exerts its oncogenic effect by inhibiting the intrinsic pathway of apoptosis by using the least squares means procedure.