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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
Capturing the swelling of solid-electrolyte interphase in lithium metal batteries
Zewen Zhang,Yuzhang Li,Rong Xu,Wei Zhu,Yanbin Li,Solomon T. Oyakhire,Yecun Wu,Jinwei Xu,Hansen Wang,Zhiao Yu,David T. Boyle,William C. Hahn,Yusheng Ye,Hao Chen,Jiayu Wan,Zhenan Bao,Wah Chiu,Yi Cui +17 more
TL;DR: A thin film vitrification method is adopted to preserve the sensitive yet critical interfaces in batteries at native liquid electrolyte environments to enable cryo–electron microscopy and spectroscopy and to report substantial swelling of the SEI on lithium metal anode in various electrolytes.
Journal ArticleDOI
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models
Silvestre Vicent,Ron Chen,Leanne C. Sayles,Chenwei Lin,Randal G. Walker,Anna K. Gillespie,Aravind Subramanian,Gregory Hinkle,Xiaoping Yang,Sakina Saif,David E. Root,Vicki D Huff,William C. Hahn,William C. Hahn,E. Alejandro Sweet-Cordero +14 more
TL;DR: An unexpected role for WT1 is identified as a key regulator of the genetic network of oncogenic KRAS and important insight is provided into the mechanisms that regulate proliferation or senescence in response to oncogens signals.
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Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase
Qing Zhang,Jinming Gu,Lianjie Li,Lianjie Li,Jiayun Liu,Biao Luo,Hiu Wing Cheung,Jesse S. Boehm,Min Ni,Christoph Geisen,David E. Root,Kornelia Polyak,Myles Brown,Andrea L. Richardson,William C. Hahn,William C. Hahn,William G. Kaelin,William G. Kaelin,Archana Bommi-Reddy +18 more
TL;DR: It is found that EglN2 inactivation decreases Cyclin D1 levels and suppresses mammary gland proliferation in vivo and support the exploration of Egln2 inhibitors as therapeutics for estrogen-dependent breast cancer and other malignancies.
Journal ArticleDOI
Nucleolin interacts with telomerase.
Shilagardi Khurts,Kenkichi Masutomi,Luvsanjav Delgermaa,Kuniaki Arai,Naoki Oishi,Hideki Mizuno,Naoyuki Hayashi,William C. Hahn,Seishi Murakami +8 more
TL;DR: It is shown that nucleolin, a major nucleolar phosphoprotein, interacts with telomerase and alters its subcellular localization and indicates that interaction of hTERT and nucleolin participates in the dynamic intracellular localization of telomersase complex.
Journal ArticleDOI
RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer
Violeta Serra,Pieter Johan Adam Eichhorn,Celina Garcia-Garcia,Yasir H. Ibrahim,Ludmila Prudkin,G. C. Sanchez,Olga Rodriguez,Pilar Anton,Josep-Lluís Parra,Sara Marlow,Maurizio Scaltriti,Jose Perez-Garcia,Aleix Prat,Joaquín Arribas,William C. Hahn,So Young Kim,José Baselga +16 more
TL;DR: It is demonstrated that overexpression of RSK3 or RSK4 supports proliferation upon PI3K inhibition both in vitro and in vivo, in part through the attenuation of the apoptotic response and upregulation of protein translation.