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William C. Hahn
Researcher at Harvard University
Publications - 515
Citations - 85047
William C. Hahn is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 130, co-authored 448 publications receiving 72191 citations. Previous affiliations of William C. Hahn include Brigham and Women's Hospital & University of Washington.
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Journal ArticleDOI
HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia
Matthew D. Galbraith,Mary A. Allen,Claire L. Bensard,Xiaoxing Wang,Xiaoxing Wang,Marie K. Schwinn,Bo Qin,Bo Qin,Henry W. Long,Danette L. Daniels,William C. Hahn,William C. Hahn,Robin D. Dowell,Joaquín M. Espinosa +13 more
TL;DR: The results provide a mechanistic link between HIF1A and CDK8, two potent oncogenes, in the cellular response to hypoxia, and employ a specific variant of the Mediator complex to stimulate RNAPII elongation.
Journal ArticleDOI
Mutational processes shape the landscape of TP53 mutations in human cancer
Andrew O. Giacomelli,Andrew O. Giacomelli,Xiaoping Yang,Robert E. Lintner,James M. McFarland,Marc Duby,Jaegil Kim,Thomas P. Howard,Thomas P. Howard,David Y. Takeda,David Y. Takeda,Seav Huong Ly,Seav Huong Ly,Eejung Kim,Hugh S. Gannon,Hugh S. Gannon,Brian Hurhula,Ted Sharpe,Amy Goodale,Briana Fritchman,Scott Steelman,Francisca Vazquez,Francisca Vazquez,Aviad Tsherniak,Andrew J. Aguirre,Andrew J. Aguirre,John G. Doench,Federica Piccioni,Charles W. M. Roberts,Charles W. M. Roberts,Matthew Meyerson,Matthew Meyerson,Gad Getz,Cory M. Johannessen,David E. Root,William C. Hahn +35 more
TL;DR: Large-scale loss-of-function screens and TP53 saturation mutagenesis screens in human cancer cell lines suggest that mutational processes combine with phenotypic selection to shape the landscape of somatic mutations at the TP53 locus.
Journal ArticleDOI
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
Scott R. Floyd,Michael E. Pacold,Michael E. Pacold,Qiuying Huang,Scott M. Clarke,Fred C. Lam,Ian G. Cannell,Bryan D. Bryson,Jonathan Rameseder,Michael J. Lee,Emily J. Blake,Anna Fydrych,Richard Ho,Benjamin A. Greenberger,Grace Chen,Amanda Maffa,Amanda M. Del Rosario,David E. Root,Anne E. Carpenter,William C. Hahn,William C. Hahn,David M. Sabatini,David M. Sabatini,Clark C. Chen,Clark C. Chen,Forest M. White,James E. Bradner,James E. Bradner,Michael B. Yaffe +28 more
TL;DR: It is discovered that an isoform of Brd4, a bromodomain and extra-terminal (BET) family member, functions as an endogenous inhibitor of DNA damage response signalling by recruiting the condensin II chromatin remodelling complex to acetylated histones through bromidomain interactions.
Journal ArticleDOI
A Genetically Defined Model for Human Ovarian Cancer
Jinsong Liu,Gong Yang,Jennifer A. Thompson-Lanza,Armand B. Glassman,Kimberly Hayes,Andrea P. Patterson,Rebecca T. Marquez,Nelly Auersperg,Yinhua Yu,William C. Hahn,Gordon B. Mills,Robert C. Bast +11 more
TL;DR: The transformed human ovarian surface epithelial cells recapitulated many features of natural ovarian cancer including a subtype of ovarian cancer histology, formation of ascites, CA125 expression, and nuclear factor-κB-mediated cytokine activation.
Journal ArticleDOI
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
James M. McFarland,Zandra V. Ho,Guillaume Kugener,Joshua M. Dempster,Phillip G. Montgomery,Jordan Bryan,John M. Krill-Burger,Thomas M Green,Francisca Vazquez,Francisca Vazquez,Jesse S. Boehm,Todd R. Golub,William C. Hahn,David E. Root,Aviad Tsherniak +14 more
TL;DR: DEMETER2, a hierarchical model coupled with model-based normalization, which allows the assessment of differential dependencies across genes and cell lines, is introduced, providing a unified resource representing the most extensive compilation of cancer cell line genetic dependencies to date.